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Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment.
Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A. Brendel M, et al. Among authors: bylund j. Mol Psychiatry. 2015 Oct;20(10):1179-87. doi: 10.1038/mp.2015.74. Epub 2015 Jun 9. Mol Psychiatry. 2015. PMID: 26055427 Free PMC article.
Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET.
Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A. Brendel M, et al. Among authors: bylund j. Mol Psychiatry. 2015 Oct;20(10):1141. doi: 10.1038/mp.2015.146. Mol Psychiatry. 2015. PMID: 26401838 No abstract available.
Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 ( SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA).
Ratni H, Ebeling M, Baird J, Bendels S, Bylund J, Chen KS, Denk N, Feng Z, Green L, Guerard M, Jablonski P, Jacobsen B, Khwaja O, Kletzl H, Ko CP, Kustermann S, Marquet A, Metzger F, Mueller B, Naryshkin NA, Paushkin SV, Pinard E, Poirier A, Reutlinger M, Weetall M, Zeller A, Zhao X, Mueller L. Ratni H, et al. Among authors: bylund j. J Med Chem. 2018 Aug 9;61(15):6501-6517. doi: 10.1021/acs.jmedchem.8b00741. Epub 2018 Jul 25. J Med Chem. 2018. PMID: 30044619
Potent and orally efficacious benzothiazole amides as TRPV1 antagonists.
Besidski Y, Brown W, Bylund J, Dabrowski M, Dautrey S, Harter M, Horoszok L, Hu Y, Johnson D, Johnstone S, Jones P, Leclerc S, Kolmodin K, Kers I, Labarre M, Labrecque D, Laird J, Lundström T, Martino J, Maudet M, Munro A, Nylöf M, Penwell A, Rotticci D, Slaitas A, Sundgren-Andersson A, Svensson M, Terp G, Villanueva H, Walpole C, Zemribo R, Griffin AM. Besidski Y, et al. Among authors: bylund j. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6205-11. doi: 10.1016/j.bmcl.2012.08.018. Epub 2012 Aug 14. Bioorg Med Chem Lett. 2012. PMID: 22939234
189 results