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Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration.
Ott M, Tomaszowski KH, Marisetty A, Kong LY, Wei J, Duna M, Blumberg K, Ji X, Jacobs C, Fuller GN, Langford LA, Huse JT, Long JP, Hu J, Li S, Weinberg JS, Prabhu SS, Sawaya R, Ferguson S, Rao G, Lang FF, Curran MA, Heimberger AB. Ott M, et al. Among authors: kong ly. JCI Insight. 2020 Sep 3;5(17):e134386. doi: 10.1172/jci.insight.134386. JCI Insight. 2020. PMID: 32721947 Free PMC article.
A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells.
Kong LY, Abou-Ghazal MK, Wei J, Chakraborty A, Sun W, Qiao W, Fuller GN, Fokt I, Grimm EA, Schmittling RJ, Archer GE Jr, Sampson JH, Priebe W, Heimberger AB. Kong LY, et al. Clin Cancer Res. 2008 Sep 15;14(18):5759-68. doi: 10.1158/1078-0432.CCR-08-0377. Clin Cancer Res. 2008. PMID: 18794085 Free PMC article.
Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway.
Wei J, Barr J, Kong LY, Wang Y, Wu A, Sharma AK, Gumin J, Henry V, Colman H, Priebe W, Sawaya R, Lang FF, Heimberger AB. Wei J, et al. Among authors: kong ly. Mol Cancer Ther. 2010 Jan;9(1):67-78. doi: 10.1158/1535-7163.MCT-09-0734. Epub 2010 Jan 6. Mol Cancer Ther. 2010. PMID: 20053772 Free PMC article.
Glioma-associated cancer-initiating cells induce immunosuppression.
Wei J, Barr J, Kong LY, Wang Y, Wu A, Sharma AK, Gumin J, Henry V, Colman H, Sawaya R, Lang FF, Heimberger AB. Wei J, et al. Among authors: kong ly. Clin Cancer Res. 2010 Jan 15;16(2):461-73. doi: 10.1158/1078-0432.CCR-09-1983. Epub 2010 Jan 12. Clin Cancer Res. 2010. Retraction in: Clin Cancer Res. 2015 May 1;21(9):2189. doi: 10.1158/1078-0432.CCR-15-0266 PMID: 20068105 Free PMC article. Retracted.
621 results