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A Clinical Metabolite of Azidothymidine Inhibits Experimental Choroidal Neovascularization and Retinal Pigmented Epithelium Degeneration.
Narendran S, Pereira F, Yerramothu P, Apicella I, Wang SB, Varshney A, Baker KL, Marion KM, Ambati M, Ambati VL, Ambati K, Sadda SR, Gelfand BD, Ambati J. Narendran S, et al. Among authors: ambati k, ambati j, ambati m, ambati vl. Invest Ophthalmol Vis Sci. 2020 Aug 3;61(10):4. doi: 10.1167/iovs.61.10.4. Invest Ophthalmol Vis Sci. 2020. PMID: 32749462 Free PMC article.
Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3.
Kleinman ME, Kaneko H, Cho WG, Dridi S, Fowler BJ, Blandford AD, Albuquerque RJ, Hirano Y, Terasaki H, Kondo M, Fujita T, Ambati BK, Tarallo V, Gelfand BD, Bogdanovich S, Baffi JZ, Ambati J. Kleinman ME, et al. Among authors: ambati bk, ambati j. Mol Ther. 2012 Jan;20(1):101-8. doi: 10.1038/mt.2011.212. Epub 2011 Oct 11. Mol Ther. 2012. PMID: 21988875 Free PMC article.
ERK1/2 activation is a therapeutic target in age-related macular degeneration.
Dridi S, Hirano Y, Tarallo V, Kim Y, Fowler BJ, Ambati BK, Bogdanovich S, Chiodo VA, Hauswirth WW, Kugel JF, Goodrich JA, Ponicsan SL, Hinton DR, Kleinman ME, Baffi JZ, Gelfand BD, Ambati J. Dridi S, et al. Among authors: ambati bk, ambati j. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13781-6. doi: 10.1073/pnas.1206494109. Epub 2012 Aug 6. Proc Natl Acad Sci U S A. 2012. PMID: 22869729 Free PMC article.
Immunology of age-related macular degeneration.
Ambati J, Atkinson JP, Gelfand BD. Ambati J, et al. Nat Rev Immunol. 2013 Jun;13(6):438-51. doi: 10.1038/nri3459. Nat Rev Immunol. 2013. PMID: 23702979 Free PMC article. Review.
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.
Fowler BJ, Gelfand BD, Kim Y, Kerur N, Tarallo V, Hirano Y, Amarnath S, Fowler DH, Radwan M, Young MT, Pittman K, Kubes P, Agarwal HK, Parang K, Hinton DR, Bastos-Carvalho A, Li S, Yasuma T, Mizutani T, Yasuma R, Wright C, Ambati J. Fowler BJ, et al. Among authors: ambati j. Science. 2014 Nov 21;346(6212):1000-3. doi: 10.1126/science.1261754. Science. 2014. PMID: 25414314 Free PMC article.
IL-18 is not therapeutic for neovascular age-related macular degeneration.
Hirano Y, Yasuma T, Mizutani T, Fowler BJ, Tarallo V, Yasuma R, Kim Y, Bastos-Carvalho A, Kerur N, Gelfand BD, Bogdanovich S, He S, Zhang X, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Nagai H, Haro I, Núñez G, Ambati BK, Hinton DR, Ambati J. Hirano Y, et al. Among authors: ambati bk, ambati j. Nat Med. 2014 Dec;20(12):1372-5. doi: 10.1038/nm.3671. Nat Med. 2014. PMID: 25473914 Free PMC article. No abstract available.
129 results