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Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ϵ variant.
Nucleic Acids Res. 2020 Sep 18;48(16):9124-9134. doi: 10.1093/nar/gkaa633.
Nucleic Acids Res. 2020.
PMID: 32756902
Free PMC article.
A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme.
Xing X, Kane DP, Bulock CR, Moore EA, Sharma S, Chabes A, Shcherbakova PV.
Xing X, et al. Among authors: bulock cr.
Nat Commun. 2019 Jan 22;10(1):374. doi: 10.1038/s41467-018-08145-2.
Nat Commun. 2019.
PMID: 30670691
Free PMC article.
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DNA polymerase δ proofreads errors made by DNA polymerase ε.
Bulock CR, Xing X, Shcherbakova PV.
Bulock CR, et al.
Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6035-6041. doi: 10.1073/pnas.1917624117. Epub 2020 Mar 2.
Proc Natl Acad Sci U S A. 2020.
PMID: 32123096
Free PMC article.
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