Zembutsu H - Search Results

1

Determination of novel CYP2D6 haplotype using the targeted sequencing followed by the long-read sequencing and the functional characterization in the Japanese population.

Fukunaga K, Hishinuma E, Hiratsuka M, Kato K, Okusaka T, Saito T, Ikeda M, Yoshida T, Zembutsu H, Iwata N, Mushiroda T. Fukunaga K, et al. Among authors: zembutsu h. J Hum Genet. 2021 Feb;66(2):139-149. doi: 10.1038/s10038-020-0815-x. Epub 2020 Aug 5. J Hum Genet. 2021. PMID: 32759992

2

Important and critical scientific aspects in pharmacogenomics analysis: lessons from controversial results of tamoxifen and CYP2D6 studies.

Kiyotani K, Mushiroda T, Zembutsu H, Nakamura Y. Kiyotani K, et al. Among authors: zembutsu h. J Hum Genet. 2013 Jun;58(6):327-33. doi: 10.1038/jhg.2013.39. Epub 2013 May 9. J Hum Genet. 2013. PMID: 23657426 Review.

3

Functional Characterization of the Effects of N-acetyltransferase 2 Alleles on N-acetylation of Eight Drugs and Worldwide Distribution of Substrate-Specific Diversity.

Fukunaga K, Kato K, Okusaka T, Saito T, Ikeda M, Yoshida T, Zembutsu H, Iwata N, Mushiroda T. Fukunaga K, et al. Among authors: zembutsu h. Front Genet. 2021 Mar 18;12:652704. doi: 10.3389/fgene.2021.652704. eCollection 2021. Front Genet. 2021. PMID: 33815485 Free PMC article.

4

Lessons for pharmacogenomics studies: association study between CYP2D6 genotype and tamoxifen response.

Kiyotani K, Mushiroda T, Hosono N, Tsunoda T, Kubo M, Aki F, Okazaki Y, Hirata K, Takatsuka Y, Okazaki M, Ohsumi S, Yamakawa T, Sasa M, Nakamura Y, Zembutsu H. Kiyotani K, et al. Among authors: zembutsu h. Pharmacogenet Genomics. 2010 Sep;20(9):565-8. doi: 10.1097/FPC.0b013e32833af231. Pharmacogenet Genomics. 2010. PMID: 20574415

5

Should CYP2D6 inhibitors be administered in conjunction with tamoxifen?

Zembutsu H, Sasa M, Kiyotani K, Mushiroda T, Nakamura Y. Zembutsu H, et al. Expert Rev Anticancer Ther. 2011 Feb;11(2):185-93. doi: 10.1586/era.10.228. Expert Rev Anticancer Ther. 2011. PMID: 21342038 Review.

6

Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients.

Kiyotani K, Mushiroda T, Imamura CK, Tanigawara Y, Hosono N, Kubo M, Sasa M, Nakamura Y, Zembutsu H. Kiyotani K, et al. Among authors: zembutsu h. Breast Cancer Res Treat. 2012 Jan;131(1):137-45. doi: 10.1007/s10549-011-1777-7. Epub 2011 Sep 23. Breast Cancer Res Treat. 2012. PMID: 21947681

7

Pharmacogenomics of tamoxifen: roles of drug metabolizing enzymes and transporters.

Kiyotani K, Mushiroda T, Nakamura Y, Zembutsu H. Kiyotani K, et al. Among authors: zembutsu h. Drug Metab Pharmacokinet. 2012;27(1):122-31. doi: 10.2133/dmpk.dmpk-11-rv-084. Epub 2011 Nov 1. Drug Metab Pharmacokinet. 2012. PMID: 22041137 Free article. Review.

8

A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese.

Kiyotani K, Mushiroda T, Tsunoda T, Morizono T, Hosono N, Kubo M, Tanigawara Y, Imamura CK, Flockhart DA, Aki F, Hirata K, Takatsuka Y, Okazaki M, Ohsumi S, Yamakawa T, Sasa M, Nakamura Y, Zembutsu H. Kiyotani K, et al. Among authors: zembutsu h. Hum Mol Genet. 2012 Apr 1;21(7):1665-72. doi: 10.1093/hmg/ddr597. Epub 2011 Dec 16. Hum Mol Genet. 2012. PMID: 22180457

9

Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy.

Kiyotani K, Mushiroda T, Sasa M, Bando Y, Sumitomo I, Hosono N, Kubo M, Nakamura Y, Zembutsu H. Kiyotani K, et al. Among authors: zembutsu h. Cancer Sci. 2008 May;99(5):995-9. doi: 10.1111/j.1349-7006.2008.00780.x. Epub 2008 Feb 24. Cancer Sci. 2008. PMID: 18294285 Free PMC article.

10

Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients.

Low SK, Kiyotani K, Mushiroda T, Daigo Y, Nakamura Y, Zembutsu H. Low SK, et al. Among authors: zembutsu h. J Hum Genet. 2009 Oct;54(10):564-71. doi: 10.1038/jhg.2009.79. Epub 2009 Aug 21. J Hum Genet. 2009. PMID: 19696793

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