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IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes.
Zhou H, Wang H, Yu M, Schugar RC, Qian W, Tang F, Liu W, Yang H, McDowell RE, Zhao J, Gao J, Dongre A, Carman JA, Yin M, Drazba JA, Dent R, Hine C, Chen YR, Smith JD, Fox PL, Brown JM, Li X. Zhou H, et al. Among authors: brown jm. Nat Immunol. 2020 Oct;21(10):1219-1231. doi: 10.1038/s41590-020-0750-1. Epub 2020 Aug 10. Nat Immunol. 2020. PMID: 32778760 Free PMC article.
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis.
Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL. Koeth RA, et al. Among authors: brown jm. Nat Med. 2013 May;19(5):576-85. doi: 10.1038/nm.3145. Epub 2013 Apr 7. Nat Med. 2013. PMID: 23563705 Free PMC article.
Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation.
Lord CC, Ferguson D, Thomas G, Brown AL, Schugar RC, Burrows A, Gromovsky AD, Betters J, Neumann C, Sacks J, Marshall S, Watts R, Schweiger M, Lee RG, Crooke RM, Graham MJ, Lathia JD, Sakaguchi TF, Lehner R, Haemmerle G, Zechner R, Brown JM. Lord CC, et al. Among authors: brown al, brown jm. Cell Rep. 2016 Jul 26;16(4):939-949. doi: 10.1016/j.celrep.2016.06.049. Epub 2016 Jul 7. Cell Rep. 2016. PMID: 27396333 Free PMC article.
The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.
Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD, Das SK, Rudel LL, Zein N, McCullough AJ, Dasarathy S, Tang WHW, Erokwu BO, Flask CA, Laakso M, Civelek M, Naga Prasad SV, Heeren J, Lusis AJ, Hazen SL, Brown JM. Schugar RC, et al. Among authors: brown al, brown jm. Cell Rep. 2017 Jun 20;19(12):2451-2461. doi: 10.1016/j.celrep.2017.05.077. Cell Rep. 2017. PMID: 28636934 Free PMC article.
Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators.
Gromovsky AD, Schugar RC, Brown AL, Helsley RN, Burrows AC, Ferguson D, Zhang R, Sansbury BE, Lee RG, Morton RE, Allende DS, Parks JS, Spite M, Brown JM. Gromovsky AD, et al. Among authors: brown al, brown jm. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):218-231. doi: 10.1161/ATVBAHA.117.309660. Epub 2017 Oct 26. Arterioscler Thromb Vasc Biol. 2018. PMID: 29074585 Free PMC article.
Loss of HDAC6 alters gut microbiota and worsens obesity.
Lieber AD, Beier UH, Xiao H, Wilkins BJ, Jiao J, Li XS, Schugar RC, Strauch CM, Wang Z, Brown JM, Hazen SL, Bokulich NA, Ruggles KV, Akimova T, Hancock WW, Blaser MJ. Lieber AD, et al. Among authors: brown jm. FASEB J. 2019 Jan;33(1):1098-1109. doi: 10.1096/fj.201701586R. Epub 2018 Aug 13. FASEB J. 2019. PMID: 30102568 Free PMC article.
Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels-Brief Report.
Shih DM, Zhu W, Schugar RC, Meng Y, Jia X, Miikeda A, Wang Z, Zieger M, Lee R, Graham M, Allayee H, Cantor RM, Mueller C, Brown JM, Hazen SL, Lusis AJ. Shih DM, et al. Among authors: brown jm. Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1045-1054. doi: 10.1161/ATVBAHA.119.312592. Arterioscler Thromb Vasc Biol. 2019. PMID: 31070450 Free PMC article.
2,117 results