Abushakra S - Search Results

1

Aducanumab, gantenerumab, BAN2401, and ALZ-801-the first wave of amyloid-targeting drugs for Alzheimer's disease with potential for near term approval.

Tolar M, Abushakra S, Hey JA, Porsteinsson A, Sabbagh M. Tolar M, et al. Among authors: abushakra s. Alzheimers Res Ther. 2020 Aug 12;12(1):95. doi: 10.1186/s13195-020-00663-w. Alzheimers Res Ther. 2020. PMID: 32787971 Free PMC article. Review.

2

Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease.

Hey JA, Yu JY, Versavel M, Abushakra S, Kocis P, Power A, Kaplan PL, Amedio J, Tolar M. Hey JA, et al. Among authors: abushakra s. Clin Pharmacokinet. 2018 Mar;57(3):315-333. doi: 10.1007/s40262-017-0608-3. Clin Pharmacokinet. 2018. PMID: 29063518 Free PMC article. Clinical Trial.

3

Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain.

Hey JA, Kocis P, Hort J, Abushakra S, Power A, Vyhnálek M, Yu JY, Tolar M. Hey JA, et al. Among authors: abushakra s. CNS Drugs. 2018 Sep;32(9):849-861. doi: 10.1007/s40263-018-0554-0. CNS Drugs. 2018. PMID: 30076539 Free PMC article. Clinical Trial.

4

The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis.

Tolar M, Abushakra S, Sabbagh M. Tolar M, et al. Among authors: abushakra s. Alzheimers Dement. 2020 Nov;16(11):1553-1560. doi: 10.1016/j.jalz.2019.09.075. Epub 2020 Jan 3. Alzheimers Dement. 2020. PMID: 31706733 Free article. Review.

5

APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline.

Abushakra S, Porsteinsson AP, Sabbagh M, Bracoud L, Schaerer J, Power A, Hey JA, Scott D, Suhy J, Tolar M; Alzheimer's Disease Neuroimaging Initiative. Abushakra S, et al. Alzheimers Dement (N Y). 2020 Dec 4;6(1):e12117. doi: 10.1002/trc2.12117. eCollection 2020. Alzheimers Dement (N Y). 2020. PMID: 33304988 Free PMC article.

6

Neurotoxic Soluble Amyloid Oligomers Drive Alzheimer's Pathogenesis and Represent a Clinically Validated Target for Slowing Disease Progression.

Tolar M, Hey J, Power A, Abushakra S. Tolar M, et al. Among authors: abushakra s. Int J Mol Sci. 2021 Jun 14;22(12):6355. doi: 10.3390/ijms22126355. Int J Mol Sci. 2021. PMID: 34198582 Free PMC article. Review.

7

Clinical Effects of Tramiprosate in APOE4/4 Homozygous Patients with Mild Alzheimer's Disease Suggest Disease Modification Potential.

Abushakra S, Porsteinsson A, Scheltens P, Sadowsky C, Vellas B, Cummings J, Gauthier S, Hey JA, Power A, Wang P, Shen L, Tolar M. Abushakra S, et al. J Prev Alzheimers Dis. 2017;4(3):149-156. doi: 10.14283/jpad.2017.26. J Prev Alzheimers Dis. 2017. PMID: 29182706 Clinical Trial.

8

Correction to: Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain.

Hey JA, Kocis P, Hort J, Abushakra S, Power A, Vyhnálek M, Yu JY, Tolar M. Hey JA, et al. Among authors: abushakra s. CNS Drugs. 2018 Dec;32(12):1185. doi: 10.1007/s40263-018-0585-6. CNS Drugs. 2018. PMID: 30421245 Free PMC article.

9

Clinical Benefits of Tramiprosate in Alzheimer's Disease Are Associated with Higher Number of APOE4 Alleles: The "APOE4 Gene-Dose Effect".

Abushakra S, Porsteinsson A, Vellas B, Cummings J, Gauthier S, Hey JA, Power A, Hendrix S, Wang P, Shen L, Sampalis J, Tolar M. Abushakra S, et al. J Prev Alzheimers Dis. 2016;3(4):219-228. doi: 10.14283/jpad.2016.115. J Prev Alzheimers Dis. 2016. PMID: 29199323

10

A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease.

Salloway S, Sperling R, Keren R, Porsteinsson AP, van Dyck CH, Tariot PN, Gilman S, Arnold D, Abushakra S, Hernandez C, Crans G, Liang E, Quinn G, Bairu M, Pastrak A, Cedarbaum JM; ELND005-AD201 Investigators. Salloway S, et al. Among authors: abushakra s. Neurology. 2011 Sep 27;77(13):1253-62. doi: 10.1212/WNL.0b013e3182309fa5. Epub 2011 Sep 14. Neurology. 2011. PMID: 21917766 Free PMC article. Clinical Trial.

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