Lotti JS - Search Results

1

Design of (R)-3-(5-Thienyl)carboxamido-2-aminopropanoic Acid Derivatives as Novel NMDA Receptor Glycine Site Agonists: Variation in Molecular Geometry to Improve Potency and Augment GluN2 Subunit-Specific Activity.

Zhao F, Atxabal U, Mariottini S, Yi F, Lotti JS, Layeux MS, Currier C, Maderia MP, Cornelison LE, Anderson CM, Schultz EP, Zhang Z, Jiang L, Gao Z, Liu N, Woodahl EL, Bunch L, Hansen KB, Clausen RP. Zhao F, et al. Among authors: lotti js. J Med Chem. 2025 Jan 23. doi: 10.1021/acs.jmedchem.4c02715. Online ahead of print. J Med Chem. 2025. PMID: 39847708

2

Evaluation of allosteric NMDA receptor modulation by GluN2A-selective antagonists using pharmacological equilibrium modeling.

Lotti JS, Jones J, Farnsworth JC, Yi F, Zhao F, Menniti FS, Volkmann RA, Clausen RP, Hansen KB. Lotti JS, et al. Mol Pharmacol. 2024 Nov 5:MOLPHARM-AR-2024-000975. doi: 10.1124/molpharm.124.000975. Online ahead of print. Mol Pharmacol. 2024. PMID: 39500597 Free article.

3

Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists.

Rouzbeh N, Rau AR, Benton AJ, Yi F, Anderson CM, Johns MR, Jensen L, Lotti JS, Holley DC, Hansen KB. Rouzbeh N, et al. Among authors: lotti js. J Gen Physiol. 2023 Jun 5;155(6):e202313340. doi: 10.1085/jgp.202313340. Epub 2023 Apr 20. J Gen Physiol. 2023. PMID: 37078900 Free PMC article.

4

Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity.

Zhao F, Mazis G, Yi F, Lotti JS, Layeux MS, Schultz EP, Bunch L, Hansen KB, Clausen RP. Zhao F, et al. Among authors: lotti js. Front Chem. 2022 Nov 17;10:1008233. doi: 10.3389/fchem.2022.1008233. eCollection 2022. Front Chem. 2022. PMID: 36465862 Free PMC article.

5

Synaptic Dysfunction by Mutations in GRIN2B: Influence of Triheteromeric NMDA Receptors on Gain-of-Function and Loss-of-Function Mutant Classification.

Elmasri M, Lotti JS, Aziz W, Steele OG, Karachaliou E, Sakimura K, Hansen KB, Penn AC. Elmasri M, et al. Among authors: lotti js. Brain Sci. 2022 Jun 15;12(6):789. doi: 10.3390/brainsci12060789. Brain Sci. 2022. PMID: 35741674 Free PMC article.

6

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity.

Zhao F, Atxabal U, Mariottini S, Yi F, Lotti JS, Rouzbeh N, Liu N, Bunch L, Hansen KB, Clausen RP. Zhao F, et al. Among authors: lotti js. J Med Chem. 2022 Jan 13;65(1):734-746. doi: 10.1021/acs.jmedchem.1c01810. Epub 2021 Dec 17. J Med Chem. 2022. PMID: 34918931 Free PMC article.

7

Isolation of Isotrichophycin C and Trichophycins G-I from a Collection of Trichodesmium thiebautii.

McManus KM, Kirk RD, Via CW, Lotti JS, Roduit AF, Teta R, Scarpato S, Mangoni A, Bertin MJ. McManus KM, et al. Among authors: lotti js. J Nat Prod. 2020 Sep 25;83(9):2664-2671. doi: 10.1021/acs.jnatprod.0c00550. Epub 2020 Aug 20. J Nat Prod. 2020. PMID: 32816476 Free PMC article.

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