Young JC - Search Results

1

Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands.

Brahimi F, Galan A, Jmaeff S, Barcelona PF, De Jay N, Dejgaard K, Young JC, Kleinman CL, Thomas DY, Saragovi HU. Brahimi F, et al. Among authors: young jc. iScience. 2020 Aug 10;23(9):101447. doi: 10.1016/j.isci.2020.101447. eCollection 2020 Sep 25. iScience. 2020. PMID: 32829283 Free PMC article.

2

Multiple 40-kDa heat-shock protein chaperones function in Tom70-dependent mitochondrial import.

Bhangoo MK, Tzankov S, Fan AC, Dejgaard K, Thomas DY, Young JC. Bhangoo MK, et al. Among authors: young jc. Mol Biol Cell. 2007 Sep;18(9):3414-28. doi: 10.1091/mbc.e07-01-0088. Epub 2007 Jun 27. Mol Biol Cell. 2007. PMID: 17596514 Free PMC article.

3

Cystic Fibrosis: Proteostatic correctors of CFTR trafficking and alternative therapeutic targets.

Hanrahan JW, Sato Y, Carlile GW, Jansen G, Young JC, Thomas DY. Hanrahan JW, et al. Among authors: young jc. Expert Opin Ther Targets. 2019 Aug;23(8):711-724. doi: 10.1080/14728222.2019.1628948. Epub 2019 Jun 9. Expert Opin Ther Targets. 2019. PMID: 31169041 Review.

4

Selective Binding of HSC70 and its Co-Chaperones to Structural Hotspots on CFTR.

Baaklini I, Gonçalves CC, Lukacs GL, Young JC. Baaklini I, et al. Among authors: young jc. Sci Rep. 2020 Mar 6;10(1):4176. doi: 10.1038/s41598-020-61107-x. Sci Rep. 2020. PMID: 32144307 Free PMC article.

5

Functional divergence between co-chaperones of Hsc70.

Tzankov S, Wong MJ, Shi K, Nassif C, Young JC. Tzankov S, et al. Among authors: young jc. J Biol Chem. 2008 Oct 3;283(40):27100-9. doi: 10.1074/jbc.M803923200. Epub 2008 Aug 6. J Biol Chem. 2008. PMID: 18684711 Free PMC article.

6

Human mitochondrial import receptor Tom70 functions as a monomer.

Fan AC, Gava LM, Ramos CH, Young JC. Fan AC, et al. Among authors: young jc. Biochem J. 2010 Aug 1;429(3):553-63. doi: 10.1042/BJ20091855. Biochem J. 2010. PMID: 20504278 Free PMC article.

7

The discovery of proteases and intramembrane proteolysis ¹.

Paschkowsky S, Hsiao JM, Young JC, Munter LM. Paschkowsky S, et al. Among authors: young jc. Biochem Cell Biol. 2019 Jun;97(3):265-269. doi: 10.1139/bcb-2018-0186. Epub 2018 Aug 13. Biochem Cell Biol. 2019. PMID: 30102867 Review.

8

Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.

Rodina A, Patel PD, Kang Y, Patel Y, Baaklini I, Wong MJ, Taldone T, Yan P, Yang C, Maharaj R, Gozman A, Patel MR, Patel HJ, Chirico W, Erdjument-Bromage H, Talele TT, Young JC, Chiosis G. Rodina A, et al. Among authors: young jc. Chem Biol. 2013 Dec 19;20(12):1469-80. doi: 10.1016/j.chembiol.2013.10.008. Epub 2013 Nov 14. Chem Biol. 2013. PMID: 24239008 Free PMC article.

9

The J Domain of Sacsin Disrupts Intermediate Filament Assembly.

Dabbaghizadeh A, Paré A, Cheng-Boivin Z, Dagher R, Minotti S, Dicaire MJ, Brais B, Young JC, Durham HD, Gentil BJ. Dabbaghizadeh A, et al. Among authors: young jc. Int J Mol Sci. 2022 Dec 12;23(24):15742. doi: 10.3390/ijms232415742. Int J Mol Sci. 2022. PMID: 36555380 Free PMC article.

10

Structures of ubiquitin-like (Ubl) and Hsp90-like domains of sacsin provide insight into pathological mutations.

Ménade M, Kozlov G, Trempe JF, Pande H, Shenker S, Wickremasinghe S, Li X, Hojjat H, Dicaire MJ, Brais B, McPherson PS, Wong MJH, Young JC, Gehring K. Ménade M, et al. Among authors: young jc. J Biol Chem. 2018 Aug 17;293(33):12832-12842. doi: 10.1074/jbc.RA118.003939. Epub 2018 Jun 26. J Biol Chem. 2018. PMID: 29945973 Free PMC article.

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