Hirano T - Search Results

1

Open-label, multicenter, dose-titration study to determine the efficacy and safety of tolvaptan in Japanese patients with hyponatremia secondary to syndrome of inappropriate secretion of antidiuretic hormone.

Arima H, Goto K, Motozawa T, Mouri M, Watanabe R, Hirano T, Ishikawa SE. Arima H, et al. Among authors: hirano t. Endocr J. 2021 Jan 28;68(1):17-29. doi: 10.1507/endocrj.EJ20-0216. Epub 2020 Aug 29. Endocr J. 2021. PMID: 32863282 Free article. Clinical Trial.

2

Tolerability of the Intravenously Administered Tolvaptan Prodrug, OPC-61815, in Patients With Congestive Heart Failure Who Have Difficulty With, or Are Incapable of, Oral Intake (TRITON-HF)　- A Phase III, Multicenter, Open-Label Trial.

Kinugawa K, Nakata E, Hirano T, Kim S. Kinugawa K, et al. Among authors: hirano t. Circ J. 2022 Jun 24;86(7):1068-1078. doi: 10.1253/circj.CJ-21-0926. Epub 2022 Mar 10. Circ J. 2022. PMID: 35264514 Free article.

3

Pharmacokinetics, Pharmacodynamics, Efficacy, and Safety of OPC-61815, a Prodrug of Tolvaptan for Intravenous Administration, in Patients With Congestive Heart Failure　- A Phase II, Multicenter, Double-Blind, Randomized, Active-Controlled Trial.

Sato N, Uno S, Yamasaki Y, Hirano T, Kim S; OPC-61815 Investigators. Sato N, et al. Among authors: hirano t. Circ J. 2022 Mar 25;86(4):699-708. doi: 10.1253/circj.CJ-21-0430. Epub 2021 Sep 11. Circ J. 2022. PMID: 34511586 Free article. Clinical Trial.

4

Real-world effectiveness and safety of tolvaptan in liver cirrhosis patients with hepatic edema: results from a post-marketing surveillance study (START study).

Sakaida I, Terai S, Kurosaki M, Okada M, Hirano T, Fukuta Y. Sakaida I, et al. Among authors: hirano t. J Gastroenterol. 2020 Aug;55(8):800-810. doi: 10.1007/s00535-020-01691-x. Epub 2020 May 9. J Gastroenterol. 2020. PMID: 32388692 Free PMC article.

5

Antidiuretic effects of a nonpeptide vasopressin V(2)-receptor agonist, OPC-51803, administered orally to rats.

Nakamura S, Hirano T, Tsujimae K, Aoyama M, Kondo K, Yamamura Y, Mori T, Tominaga M. Nakamura S, et al. Among authors: hirano t. J Pharmacol Exp Ther. 2000 Dec;295(3):1005-11. J Pharmacol Exp Ther. 2000. PMID: 11082435

6

Antidiuretic effects of a novel nonpeptide vasopressin V(2)-receptor agonist, OPC-51803, administered orally to dogs.

Nakamura S, Hirano T, Onogawa T, Itoh S, Hashimoto A, Yamamura Y, Kondo K, Mori T, Kambe T. Nakamura S, et al. Among authors: hirano t. J Pharmacol Sci. 2004 Apr;94(4):426-33. doi: 10.1254/jphs.94.426. J Pharmacol Sci. 2004. PMID: 15107583 Free article.

7

Effects of the V(2)-receptor antagonist OPC-41061 and the loop diuretic furosemide alone and in combination in rats.

Hirano T, Yamamura Y, Nakamura S, Onogawa T, Mori T. Hirano T, et al. J Pharmacol Exp Ther. 2000 Jan;292(1):288-94. J Pharmacol Exp Ther. 2000. PMID: 10604960

8

Real-world hospital mortality of liver cirrhosis inpatients in Japan: a large-scale cohort study using a medical claims database: Prognosis of liver cirrhosis.

Yatsuhashi H, Sano H, Hirano T, Shibasaki Y. Yatsuhashi H, et al. Among authors: hirano t. Hepatol Res. 2021 Jun;51(6):682-693. doi: 10.1111/hepr.13635. Epub 2021 Mar 27. Hepatol Res. 2021. PMID: 33710718

9

OPC-41061, a highly potent human vasopressin V2-receptor antagonist: pharmacological profile and aquaretic effect by single and multiple oral dosing in rats.

Yamamura Y, Nakamura S, Itoh S, Hirano T, Onogawa T, Yamashita T, Yamada Y, Tsujimae K, Aoyama M, Kotosai K, Ogawa H, Yamashita H, Kondo K, Tominaga M, Tsujimoto G, Mori T. Yamamura Y, et al. Among authors: hirano t. J Pharmacol Exp Ther. 1998 Dec;287(3):860-7. J Pharmacol Exp Ther. 1998. PMID: 9864265

10

Functional and structural changes in end-stage kidney disease due to glomerulonephritis induced by the recombinant alpha3(IV)NC1 domain.

Nishibayashi S, Hattori K, Hirano T, Uehara K, Nakano Y, Aihara M, Yamada Y, Muraguchi M, Iwata F, Takiguchi Y. Nishibayashi S, et al. Among authors: hirano t. Exp Anim. 2010;59(2):157-70. doi: 10.1538/expanim.59.157. Exp Anim. 2010. PMID: 20484849 Free article.

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