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Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production.
Du X, Moore J, Blank BR, Eksterowicz J, Sutimantanapi D, Yuen N, Metzger T, Chan B, Huang T, Chen X, Chen Y, Duong F, Kong W, Chang JH, Sun J, Zavorotinskaya T, Ye Q, Junttila MR, Ndubaku C, Friedman LS, Fantin VR, Sun D. Du X, et al. Among authors: metzger t. J Med Chem. 2020 Sep 24;63(18):10433-10459. doi: 10.1021/acs.jmedchem.0c01086. Epub 2020 Sep 9. J Med Chem. 2020. PMID: 32865411
Spontaneous development of autoimmune uveitis Is CCR2 dependent.
Chen YF, Zhou D, Metzger T, Gallup M, Jeanne M, Gould DB, Anderson MS, McNamara NA. Chen YF, et al. Among authors: metzger t. Am J Pathol. 2014 Jun;184(6):1695-705. doi: 10.1016/j.ajpath.2014.02.024. Epub 2014 Apr 13. Am J Pathol. 2014. PMID: 24736166 Free PMC article.
Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells.
Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS. Gardner JM, et al. Among authors: metzger tc. Immunity. 2013 Sep 19;39(3):560-72. doi: 10.1016/j.immuni.2013.08.005. Epub 2013 Aug 29. Immunity. 2013. PMID: 23993652 Free PMC article.
Myocarditis: a defect in central immune tolerance?
Metzger TC, Anderson MS. Metzger TC, et al. J Clin Invest. 2011 Apr;121(4):1251-3. doi: 10.1172/JCI57211. Epub 2011 Mar 23. J Clin Invest. 2011. PMID: 21436581 Free PMC article.
BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease.
Shum AK, Alimohammadi M, Tan CL, Cheng MH, Metzger TC, Law CS, Lwin W, Perheentupa J, Bour-Jordan H, Carel JC, Husebye ES, De Luca F, Janson C, Sargur R, Dubois N, Kajosaari M, Wolters PJ, Chapman HA, Kämpe O, Anderson MS. Shum AK, et al. Sci Transl Med. 2013 Oct 9;5(206):206ra139. doi: 10.1126/scitranslmed.3006998. Sci Transl Med. 2013. PMID: 24107778 Free PMC article.
Control of central and peripheral tolerance by Aire.
Metzger TC, Anderson MS. Metzger TC, et al. Immunol Rev. 2011 May;241(1):89-103. doi: 10.1111/j.1600-065X.2011.01008.x. Immunol Rev. 2011. PMID: 21488892 Free PMC article. Review.
157 results