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Lactate Dehydrogenase A Depletion Alters MyC-CaP Tumor Metabolism, Microenvironment, and CAR T Cell Therapy.
Mane MM, Cohen IJ, Ackerstaff E, Shalaby K, Ijoma JN, Ko M, Maeda M, Albeg AS, Vemuri K, Satagopan J, Moroz A, Zurita J, Shenker L, Shindo M, Nickles T, Nikolov E, Moroz MA, Koutcher JA, Serganova I, Ponomarev V, Blasberg RG. Mane MM, et al. Among authors: koutcher ja. Mol Ther Oncolytics. 2020 Jul 21;18:382-395. doi: 10.1016/j.omto.2020.07.006. eCollection 2020 Sep 25. Mol Ther Oncolytics. 2020. PMID: 32913888 Free PMC article.
Tumor stroma interaction is mediated by monocarboxylate metabolism.
Patel BB, Ackerstaff E, Serganova IS, Kerrigan JE, Blasberg RG, Koutcher JA, Banerjee D. Patel BB, et al. Among authors: koutcher ja. Exp Cell Res. 2017 Mar 1;352(1):20-33. doi: 10.1016/j.yexcr.2017.01.013. Epub 2017 Jan 26. Exp Cell Res. 2017. PMID: 28132882 Free PMC article.
Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors.
Rizwan A, Serganova I, Khanin R, Karabeber H, Ni X, Thakur S, Zakian KL, Blasberg R, Koutcher JA. Rizwan A, et al. Among authors: koutcher ja. Clin Cancer Res. 2013 Sep 15;19(18):5158-69. doi: 10.1158/1078-0432.CCR-12-3300. Epub 2013 Jul 5. Clin Cancer Res. 2013. PMID: 23833310 Free PMC article.
Inhibition of prostate cancer proliferation by Deferiprone.
Simões RV, Veeraperumal S, Serganova IS, Kruchevsky N, Varshavsky J, Blasberg RG, Ackerstaff E, Koutcher JA. Simões RV, et al. Among authors: koutcher ja. NMR Biomed. 2017 Jun;30(6):10.1002/nbm.3712. doi: 10.1002/nbm.3712. Epub 2017 Mar 8. NMR Biomed. 2017. PMID: 28272795 Free PMC article.
CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours.
Zappasodi R, Serganova I, Cohen IJ, Maeda M, Shindo M, Senbabaoglu Y, Watson MJ, Leftin A, Maniyar R, Verma S, Lubin M, Ko M, Mane MM, Zhong H, Liu C, Ghosh A, Abu-Akeel M, Ackerstaff E, Koutcher JA, Ho PC, Delgoffe GM, Blasberg R, Wolchok JD, Merghoub T. Zappasodi R, et al. Among authors: koutcher ja. Nature. 2021 Mar;591(7851):652-658. doi: 10.1038/s41586-021-03326-4. Epub 2021 Feb 15. Nature. 2021. PMID: 33588426 Free PMC article.
227 results