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SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α.
Mira E, Carmona-Rodríguez L, Pérez-Villamil B, Casas J, Fernández-Aceñero MJ, Martínez-Rey D, Martín-González P, Heras-Murillo I, Paz-Cabezas M, Tardáguila M, Oury TD, Martín-Puig S, Lacalle RA, Fabriás G, Díaz-Rubio E, Mañes S. Mira E, et al. Among authors: martinez rey d. Nat Commun. 2018 Feb 8;9(1):575. doi: 10.1038/s41467-018-03079-1. Nat Commun. 2018. PMID: 29422508 Free PMC article.
SOD3 induces a HIF-2α-dependent program in endothelial cells that provides a selective signal for tumor infiltration by T cells.
Carmona-Rodríguez L, Martínez-Rey D, Fernández-Aceñero MJ, González-Martín A, Paz-Cabezas M, Rodríguez-Rodríguez N, Pérez-Villamil B, Sáez ME, Díaz-Rubio E, Mira E, Mañes S. Carmona-Rodríguez L, et al. Among authors: martinez rey d. J Immunother Cancer. 2020 Jun;8(1):e000432. doi: 10.1136/jitc-2019-000432. J Immunother Cancer. 2020. PMID: 32591431 Free PMC article.