Sansom OJ - Search Results

1

Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1.

Dunbar K, Valanciute A, Lima ACS, Vinuela PF, Jamieson T, Rajasekaran V, Blackmur J, Ochocka-Fox AM, Guazzelli A, Cammareri P, Arends MJ, Sansom OJ, Myant KB, Farrington SM, Dunlop MG, Din FVN. Dunbar K, et al. Among authors: sansom oj. Cell Mol Gastroenterol Hepatol. 2021;11(2):465-489. doi: 10.1016/j.jcmgh.2020.09.010. Epub 2020 Sep 22. Cell Mol Gastroenterol Hepatol. 2021. PMID: 32971322 Free PMC article.

2

In vivo administration of O(6)-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine.

Toft NJ, Sansom OJ, Brookes RA, Arends MJ, Wood M, Margison GP, Winton DJ, Clarke AR. Toft NJ, et al. Among authors: sansom oj. Carcinogenesis. 2000 Apr;21(4):593-8. doi: 10.1093/carcin/21.4.593. Carcinogenesis. 2000. PMID: 10753191

3

Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice.

Sansom OJ, Stark LA, Dunlop MG, Clarke AR. Sansom OJ, et al. Cancer Res. 2001 Oct 1;61(19):7060-4. Cancer Res. 2001. PMID: 11585736

4

Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background.

Toft NJ, Curtis LJ, Sansom OJ, Leitch AL, Wyllie AH, te Riele H, Arends MJ, Clarke AR. Toft NJ, et al. Among authors: sansom oj. Oncogene. 2002 Sep 12;21(41):6299-306. doi: 10.1038/sj.onc.1205727. Oncogene. 2002. PMID: 12214270

5

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.

Sansom OJ, Meniel V, Wilkins JA, Cole AM, Oien KA, Marsh V, Jamieson TJ, Guerra C, Ashton GH, Barbacid M, Clarke AR. Sansom OJ, et al. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14122-7. doi: 10.1073/pnas.0604130103. Epub 2006 Sep 7. Proc Natl Acad Sci U S A. 2006. PMID: 16959882 Free PMC article.

6

Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer.

Stark LA, Reid K, Sansom OJ, Din FV, Guichard S, Mayer I, Jodrell DI, Clarke AR, Dunlop MG. Stark LA, et al. Among authors: sansom oj. Carcinogenesis. 2007 May;28(5):968-76. doi: 10.1093/carcin/bgl220. Epub 2006 Nov 28. Carcinogenesis. 2007. PMID: 17132819

7

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.

Dikovskaya D, Schiffmann D, Newton IP, Oakley A, Kroboth K, Sansom O, Jamieson TJ, Meniel V, Clarke A, Näthke IS. Dikovskaya D, et al. J Cell Biol. 2007 Jan 15;176(2):183-95. doi: 10.1083/jcb.200610099. J Cell Biol. 2007. PMID: 17227893 Free PMC article.

8

Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis.

Patek CE, Arends MJ, Wallace WA, Luo F, Hagan S, Brownstein DG, Rose L, Devenney PS, Walker M, Plowman SJ, Berry RL, Kolch W, Sansom OJ, Harrison DJ, Hooper ML. Patek CE, et al. Among authors: sansom oj. Exp Cell Res. 2008 Mar 10;314(5):1105-14. doi: 10.1016/j.yexcr.2007.11.004. Epub 2007 Nov 17. Exp Cell Res. 2008. PMID: 18062963

9

The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.

Patek CE, Arends MJ, Rose L, Luo F, Walker M, Devenney PS, Berry RL, Lawrence NJ, Ridgway RA, Sansom OJ, Hooper ML. Patek CE, et al. Among authors: sansom oj. BMC Gastroenterol. 2008 Jun 13;8:24. doi: 10.1186/1471-230X-8-24. BMC Gastroenterol. 2008. PMID: 18554389 Free PMC article.

10

Deficiency of Mbd2 attenuates Wnt signaling.

Phesse TJ, Parry L, Reed KR, Ewan KB, Dale TC, Sansom OJ, Clarke AR. Phesse TJ, et al. Among authors: sansom oj. Mol Cell Biol. 2008 Oct;28(19):6094-103. doi: 10.1128/MCB.00539-08. Epub 2008 Jul 21. Mol Cell Biol. 2008. PMID: 18644872 Free PMC article.

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