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Integration of innate immune signalling by caspase-8 cleavage of N4BP1.
Gitlin AD, Heger K, Schubert AF, Reja R, Yan D, Pham VC, Suto E, Zhang J, Kwon YC, Freund EC, Kang J, Pham A, Caothien R, Bacarro N, Hinkle T, Xu M, McKenzie BS, Haley B, Lee WP, Lill JR, Roose-Girma M, Dohse M, Webster JD, Newton K, Dixit VM. Gitlin AD, et al. Among authors: heger k. Nature. 2020 Nov;587(7833):275-280. doi: 10.1038/s41586-020-2796-5. Epub 2020 Sep 24. Nature. 2020. PMID: 32971525
OTULIN limits cell death and inflammation by deubiquitinating LUBAC.
Heger K, Wickliffe KE, Ndoja A, Zhang J, Murthy A, Dugger DL, Maltzman A, de Sousa E Melo F, Hung J, Zeng Y, Verschueren E, Kirkpatrick DS, Vucic D, Lee WP, Roose-Girma M, Newman RJ, Warming S, Hsiao YC, Kőműves LG, Webster JD, Newton K, Dixit VM. Heger K, et al. Nature. 2018 Jul;559(7712):120-124. doi: 10.1038/s41586-018-0256-2. Epub 2018 Jun 27. Nature. 2018. PMID: 29950720
TBK1 and IKKε restrain cell death.
Heger K, Dixit VM. Heger K, et al. Nat Cell Biol. 2018 Dec;20(12):1330-1331. doi: 10.1038/s41556-018-0239-4. Nat Cell Biol. 2018. PMID: 30482939 No abstract available.
Slow integrin-dependent migration organizes networks of tissue-resident mast cells.
Kaltenbach L, Martzloff P, Bambach SK, Aizarani N, Mihlan M, Gavrilov A, Glaser KM, Stecher M, Thünauer R, Thiriot A, Heger K, Kierdorf K, Wienert S, von Andrian UH, Schmidt-Supprian M, Nerlov C, Klauschen F, Roers A, Bajénoff M, Grün D, Lämmermann T. Kaltenbach L, et al. Among authors: heger k. Nat Immunol. 2023 Jun;24(6):915-924. doi: 10.1038/s41590-023-01493-2. Epub 2023 Apr 20. Nat Immunol. 2023. PMID: 37081147 Free PMC article.
A20-deficient mast cells exacerbate inflammatory responses in vivo.
Heger K, Fierens K, Vahl JC, Aszodi A, Peschke K, Schenten D, Hammad H, Beyaert R, Saur D, van Loo G, Roers A, Lambrecht BN, Kool M, Schmidt-Supprian M. Heger K, et al. PLoS Biol. 2014 Jan;12(1):e1001762. doi: 10.1371/journal.pbio.1001762. Epub 2014 Jan 14. PLoS Biol. 2014. PMID: 24453940 Free PMC article.
B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice.
Chu Y, Vahl JC, Kumar D, Heger K, Bertossi A, Wójtowicz E, Soberon V, Schenten D, Mack B, Reutelshöfer M, Beyaert R, Amann K, van Loo G, Schmidt-Supprian M. Chu Y, et al. Among authors: heger k. Blood. 2011 Feb 17;117(7):2227-36. doi: 10.1182/blood-2010-09-306019. Epub 2010 Nov 18. Blood. 2011. PMID: 21088135 Free article.
Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.
Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA, Zöller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J, Repsilber D, Geerlof A, Blum H, Wurst W, Heikenwälder M, Schmidt-Supprian M, Heissmeyer V. Vogel KU, et al. Among authors: heger k. Immunity. 2013 Apr 18;38(4):655-68. doi: 10.1016/j.immuni.2012.12.004. Epub 2013 Apr 11. Immunity. 2013. PMID: 23583643 Free article.
36 results