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The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication.
Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, Séveno M, Durroux T, Junier MP, Schlecht-Louf G, Bachelerie F, Schütz D, Stumm R, Smit MJ, Guérineau NC, Chaumont-Dubel S, Marin P. Fumagalli A, et al. Among authors: smit mj. Nat Commun. 2020 Sep 25;11(1):4855. doi: 10.1038/s41467-020-18634-y. Nat Commun. 2020. PMID: 32978390 Free PMC article.
CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome.
de Wit RH, Heukers R, Brink HJ, Arsova A, Maussang D, Cutolo P, Strubbe B, Vischer HF, Bachelerie F, Smit MJ. de Wit RH, et al. Among authors: smit mj. J Pharmacol Exp Ther. 2017 Oct;363(1):35-44. doi: 10.1124/jpet.117.242735. Epub 2017 Aug 2. J Pharmacol Exp Ther. 2017. PMID: 28768817
The Role of ACKR3 in Breast, Lung, and Brain Cancer.
Neves M, Fumagalli A, van den Bor J, Marin P, Smit MJ, Mayor F. Neves M, et al. Among authors: smit mj. Mol Pharmacol. 2019 Dec;96(6):819-825. doi: 10.1124/mol.118.115279. Epub 2019 Feb 11. Mol Pharmacol. 2019. PMID: 30745320 Free article. Review.
Computationally designed GPCR quaternary structures bias signaling pathway activation.
Paradis JS, Feng X, Murat B, Jefferson RE, Sokrat B, Szpakowska M, Hogue M, Bergkamp ND, Heydenreich FM, Smit MJ, Chevigné A, Bouvier M, Barth P. Paradis JS, et al. Among authors: smit mj. Nat Commun. 2022 Nov 11;13(1):6826. doi: 10.1038/s41467-022-34382-7. Nat Commun. 2022. PMID: 36369272 Free PMC article.
Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies.
Perez Almeria CV, Otun O, Schlimgen R, Lamme TD, Crudden C, Youssef N, Musli L, Jenjak S, Bobkov V, Drube J, Hoffmann C, Volkman BF, Granier S, Bechara C, Siderius M, Heukers R, Schafer CT, Smit MJ. Perez Almeria CV, et al. Among authors: smit mj. bioRxiv [Preprint]. 2024 Nov 4:2024.11.04.621790. doi: 10.1101/2024.11.04.621790. bioRxiv. 2024. PMID: 39574661 Free PMC article. Preprint.
272 results