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CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.
Bengoa-Vergniory N, Faggiani E, Ramos-Gonzalez P, Kirkiz E, Connor-Robson N, Brown LV, Siddique I, Li Z, Vingill S, Cioroch M, Cavaliere F, Threlfell S, Roberts B, Schrader T, Klärner FG, Cragg S, Dehay B, Bitan G, Matute C, Bezard E, Wade-Martins R. Bengoa-Vergniory N, et al. Among authors: connor robson n. Nat Commun. 2020 Sep 28;11(1):4885. doi: 10.1038/s41467-020-18689-x. Nat Commun. 2020. PMID: 32985503 Free PMC article.
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
Sloan M, Alegre-Abarrategui J, Potgieter D, Kaufmann AK, Exley R, Deltheil T, Threlfell S, Connor-Robson N, Brimblecombe K, Wallings R, Cioroch M, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Dodson PD, Wade-Martins R. Sloan M, et al. Hum Mol Genet. 2016 Mar 1;25(5):951-63. doi: 10.1093/hmg/ddv628. Epub 2016 Jan 6. Hum Mol Genet. 2016. PMID: 26744332 Free PMC article.
"LRRK2: Autophagy and Lysosomal Activity".
Madureira M, Connor-Robson N, Wade-Martins R. Madureira M, et al. Front Neurosci. 2020 May 25;14:498. doi: 10.3389/fnins.2020.00498. eCollection 2020. Front Neurosci. 2020. PMID: 32523507 Free PMC article. Review.
Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol.
Threlfell S, Mohammadi AS, Ryan BJ, Connor-Robson N, Platt NJ, Anand R, Serres F, Sharp T, Bengoa-Vergniory N, Wade-Martins R, Ewing A, Cragg SJ, Brimblecombe KR. Threlfell S, et al. Among authors: connor robson n. Front Cell Neurosci. 2021 Apr 15;15:658244. doi: 10.3389/fncel.2021.658244. eCollection 2021. Front Cell Neurosci. 2021. PMID: 33935654 Free PMC article.
27 results