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RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice.
Karunakaran D, Turner AW, Duchez AC, Soubeyrand S, Rasheed A, Smyth D, Cook DP, Nikpay M, Kandiah JW, Pan C, Geoffrion M, Lee R, Boytard L, Wyatt H, Nguyen MA, Lau P, Laakso M, Ramkhelawon B, Alvarez M, Pietiläinen KH, Pajukanta P, Vanderhyden BC, Liu P, Berger SB, Gough PJ, Bertin J, Harper ME, Lusis AJ, McPherson R, Rayner KJ. Karunakaran D, et al. Among authors: lau p. Nat Metab. 2020 Oct;2(10):1113-1125. doi: 10.1038/s42255-020-00279-2. Epub 2020 Sep 28. Nat Metab. 2020. PMID: 32989316 Free PMC article.
Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus.
Jarinova O, Stewart AF, Roberts R, Wells G, Lau P, Naing T, Buerki C, McLean BW, Cook RC, Parker JS, McPherson R. Jarinova O, et al. Among authors: lau p. Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1671-7. doi: 10.1161/ATVBAHA.109.189522. Epub 2009 Jul 10. Arterioscler Thromb Vasc Biol. 2009. PMID: 19592466
Adiposity significantly modifies genetic risk for dyslipidemia.
Cole CB, Nikpay M, Lau P, Stewart AF, Davies RW, Wells GA, Dent R, McPherson R. Cole CB, et al. Among authors: lau p. J Lipid Res. 2014 Nov;55(11):2416-22. doi: 10.1194/jlr.P052522. Epub 2014 Sep 15. J Lipid Res. 2014. PMID: 25225679 Free PMC article.
947 results