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IK1-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: an improved cardiomyocyte model to investigate inherited arrhythmia syndromes.
Vaidyanathan R, Markandeya YS, Kamp TJ, Makielski JC, January CT, Eckhardt LL. Vaidyanathan R, et al. Among authors: makielski jc. Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1611-21. doi: 10.1152/ajpheart.00481.2015. Epub 2016 Apr 8. Am J Physiol Heart Circ Physiol. 2016. PMID: 27059077 Free PMC article.
Genetic Loss of IK1 Causes Adrenergic-Induced Phase 3 Early Afterdepolariz ations and Polymorphic and Bidirectional Ventricular Tachycardia.
Reilly L, Alvarado FJ, Lang D, Abozeid S, Van Ert H, Spellman C, Warden J, Makielski JC, Glukhov AV, Eckhardt LL. Reilly L, et al. Among authors: makielski jc. Circ Arrhythm Electrophysiol. 2020 Sep;13(9):e008638. doi: 10.1161/CIRCEP.120.008638. Epub 2020 Aug 4. Circ Arrhythm Electrophysiol. 2020. PMID: 32931337 Free PMC article.
Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I(Kr).
Rajamani S, Anderson CL, Valdivia CR, Eckhardt LL, Foell JD, Robertson GA, Kamp TJ, Makielski JC, Anson BD, January CT. Rajamani S, et al. Among authors: makielski jc. Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1278-88. doi: 10.1152/ajpheart.00777.2005. Epub 2005 Oct 14. Am J Physiol Heart Circ Physiol. 2006. PMID: 16227340 Free article.
Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia.
Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, January CT, Healy KE, Kamp TJ, Yamanaka S, Conklin BR. Spencer CI, et al. Among authors: makielski jc. Stem Cell Reports. 2014 Aug 12;3(2):269-81. doi: 10.1016/j.stemcr.2014.06.003. Epub 2014 Jul 4. Stem Cell Reports. 2014. PMID: 25254341 Free PMC article.
146 results