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Page 1
Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs.
Hadi K, Yao X, Behr JM, Deshpande A, Xanthopoulakis C, Tian H, Kudman S, Rosiene J, Darmofal M, DeRose J, Mortensen R, Adney EM, Shaiber A, Gajic Z, Sigouros M, Eng K, Wala JA, Wrzeszczyński KO, Arora K, Shah M, Emde AK, Felice V, Frank MO, Darnell RB, Ghandi M, Huang F, Dewhurst S, Maciejowski J, de Lange T, Setton J, Riaz N, Reis-Filho JS, Powell S, Knowles DA, Reznik E, Mishra B, Beroukhim R, Zody MC, Robine N, Oman KM, Sanchez CA, Kuhner MK, Smith LP, Galipeau PC, Paulson TG, Reid BJ, Li X, Wilkes D, Sboner A, Mosquera JM, Elemento O, Imielinski M. Hadi K, et al. Among authors: de lange t. Cell. 2020 Oct 1;183(1):197-210.e32. doi: 10.1016/j.cell.2020.08.006. Cell. 2020. PMID: 33007263 Free PMC article.
Chromothripsis and Kataegis Induced by Telomere Crisis.
Maciejowski J, Li Y, Bosco N, Campbell PJ, de Lange T. Maciejowski J, et al. Among authors: de lange t. Cell. 2015 Dec 17;163(7):1641-54. doi: 10.1016/j.cell.2015.11.054. Cell. 2015. PMID: 26687355 Free PMC article.
Telomeres in cancer: tumour suppression and genome instability.
Maciejowski J, de Lange T. Maciejowski J, et al. Among authors: de lange t. Nat Rev Mol Cell Biol. 2017 Mar;18(3):175-186. doi: 10.1038/nrm.2016.171. Epub 2017 Jan 18. Nat Rev Mol Cell Biol. 2017. PMID: 28096526 Free PMC article. Review.
Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb.
Yang Z, Maciejowski J, de Lange T. Yang Z, et al. Among authors: de lange t. Mol Cancer Res. 2017 Nov;15(11):1579-1586. doi: 10.1158/1541-7786.MCR-17-0084. Epub 2017 Aug 15. Mol Cancer Res. 2017. PMID: 28811362 Free PMC article.
APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis.
Maciejowski J, Chatzipli A, Dananberg A, Chu K, Toufektchan E, Klimczak LJ, Gordenin DA, Campbell PJ, de Lange T. Maciejowski J, et al. Among authors: de lange t. Nat Genet. 2020 Sep;52(9):884-890. doi: 10.1038/s41588-020-0667-5. Epub 2020 Jul 27. Nat Genet. 2020. PMID: 32719516 Free PMC article.
Structural variant evolution after telomere crisis.
Dewhurst SM, Yao X, Rosiene J, Tian H, Behr J, Bosco N, Takai KK, de Lange T, Imieliński M. Dewhurst SM, et al. Among authors: de lange t. Nat Commun. 2021 Apr 7;12(1):2093. doi: 10.1038/s41467-021-21933-7. Nat Commun. 2021. PMID: 33828097 Free PMC article.
Most large structural variants in cancer genomes can be detected without long reads.
Choo ZN, Behr JM, Deshpande A, Hadi K, Yao X, Tian H, Takai K, Zakusilo G, Rosiene J, Da Cruz Paula A, Weigelt B, Setton J, Riaz N, Powell SN, Busam K, Shoushtari AN, Ariyan C, Reis-Filho J, de Lange T, Imieliński M. Choo ZN, et al. Among authors: de lange t. Nat Genet. 2023 Dec;55(12):2139-2148. doi: 10.1038/s41588-023-01540-6. Epub 2023 Nov 9. Nat Genet. 2023. PMID: 37945902 Free PMC article.
TRF2 protects human telomeres from end-to-end fusions.
van Steensel B, Smogorzewska A, de Lange T. van Steensel B, et al. Among authors: de lange t. Cell. 1998 Feb 6;92(3):401-13. doi: 10.1016/s0092-8674(00)80932-0. Cell. 1998. PMID: 9476899 Free article.
275 results