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Rapid selection of a human monoclonal antibody that potently neutralizes SARS-CoV-2 in two animal models.
Li W, Drelich A, Martinez DR, Gralinski L, Chen C, Sun Z, Schäfer A, Leist SR, Liu X, Zhelev D, Zhang L, Peterson EC, Conard A, Mellors JW, Tseng CT, Baric RS, Dimitrov DS. Li W, et al. Among authors: drelich a. bioRxiv [Preprint]. 2020 Jun 2:2020.05.13.093088. doi: 10.1101/2020.05.13.093088. bioRxiv. 2020. PMID: 32511413 Free PMC article. Preprint.
A novel receptor-binding domain (RBD)-based mRNA vaccine against SARS-CoV-2.
Tai W, Zhang X, Drelich A, Shi J, Hsu JC, Luchsinger L, Hillyer CD, Tseng CK, Jiang S, Du L. Tai W, et al. Among authors: drelich a. Cell Res. 2020 Oct;30(10):932-935. doi: 10.1038/s41422-020-0387-5. Epub 2020 Aug 5. Cell Res. 2020. PMID: 32759966 Free PMC article. No abstract available.
High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models.
Li W, Schäfer A, Kulkarni SS, Liu X, Martinez DR, Chen C, Sun Z, Leist SR, Drelich A, Zhang L, Ura ML, Berezuk A, Chittori S, Leopold K, Mannar D, Srivastava SS, Zhu X, Peterson EC, Tseng CT, Mellors JW, Falzarano D, Subramaniam S, Baric RS, Dimitrov DS. Li W, et al. Among authors: drelich a. Cell. 2020 Oct 15;183(2):429-441.e16. doi: 10.1016/j.cell.2020.09.007. Epub 2020 Sep 4. Cell. 2020. PMID: 32941803 Free PMC article.
Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection.
Li W, Chen C, Drelich A, Martinez DR, Gralinski LE, Sun Z, Schäfer A, Kulkarni SS, Liu X, Leist SR, Zhelev DV, Zhang L, Kim YJ, Peterson EC, Conard A, Mellors JW, Tseng CK, Falzarano D, Baric RS, Dimitrov DS. Li W, et al. Among authors: drelich a. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29832-29838. doi: 10.1073/pnas.2010197117. Epub 2020 Nov 2. Proc Natl Acad Sci U S A. 2020. PMID: 33139569 Free PMC article.
The Development of a Novel Nanobody Therapeutic for SARS-CoV-2.
Ye G, Gallant JP, Massey C, Shi K, Tai W, Zheng J, Odle AE, Vickers MA, Shang J, Wan Y, Drelich A, Kempaiah KR, Tat V, Perlman S, Du L, Tseng CT, Aihara H, LeBeau AM, Li F. Ye G, et al. Among authors: drelich a. bioRxiv [Preprint]. 2020 Nov 17:2020.11.17.386532. doi: 10.1101/2020.11.17.386532. bioRxiv. 2020. Update in: Elife. 2021 Aug 02;10:e64815. doi: 10.7554/eLife.64815. PMID: 33236012 Free PMC article. Updated. Preprint.
A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.
Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Kocurek KI, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, Hirata K, Yoon MC, Beck S, Carlin AF, Clark AE, Beretta L, Maneval D, Hook V, Frueh F, Hurst BL, Wang H, Raushel FM, O'Donoghue AJ, de Siqueira-Neto JL, Meek TD, McKerrow JH. Mellott DM, et al. Among authors: drelich a. ACS Chem Biol. 2021 Apr 16;16(4):642-650. doi: 10.1021/acschembio.0c00875. Epub 2021 Mar 31. ACS Chem Biol. 2021. PMID: 33787221
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.
Ashhurst AS, Tang AH, Fajtová P, Yoon MC, Aggarwal A, Bedding MJ, Stoye A, Beretta L, Pwee D, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, Tseng CT, Larance M, Turville S, Gerwick WH, O'Donoghue AJ, Payne RJ. Ashhurst AS, et al. Among authors: drelich a. J Med Chem. 2022 Feb 24;65(4):2956-2970. doi: 10.1021/acs.jmedchem.1c01494. Epub 2021 Nov 3. J Med Chem. 2022. PMID: 34730959 Free PMC article.
61 results