Richards MW - Search Results

1

Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma.

Poon E, Liang T, Jamin Y, Walz S, Kwok C, Hakkert A, Barker K, Urban Z, Thway K, Zeid R, Hallsworth A, Box G, Ebus ME, Licciardello MP, Sbirkov Y, Lazaro G, Calton E, Costa BM, Valenti M, De Haven Brandon A, Webber H, Tardif N, Almeida GS, Christova R, Boysen G, Richards MW, Barone G, Ford A, Bayliss R, Clarke PA, De Bono J, Gray NS, Blagg J, Robinson SP, Eccles SA, Zheleva D, Bradner JE, Molenaar J, Vivanco I, Eilers M, Workman P, Lin CY, Chesler L. Poon E, et al. Among authors: richards mw. J Clin Invest. 2020 Nov 2;130(11):5875-5892. doi: 10.1172/JCI134132. J Clin Invest. 2020. PMID: 33016930 Free PMC article.

2

Insights into the conformational variability and regulation of human Nek2 kinase.

Westwood I, Cheary DM, Baxter JE, Richards MW, van Montfort RL, Fry AM, Bayliss R. Westwood I, et al. Among authors: richards mw. J Mol Biol. 2009 Feb 20;386(2):476-85. doi: 10.1016/j.jmb.2008.12.033. Epub 2008 Dec 24. J Mol Biol. 2009. PMID: 19124027 Free PMC article.

3

A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation.

Richards MW, Leung JW, Roe SM, Li K, Chen J, Bayliss R. Richards MW, et al. J Mol Biol. 2010 Feb 5;395(5):908-15. doi: 10.1016/j.jmb.2009.11.029. Epub 2009 Nov 17. J Mol Biol. 2010. PMID: 19925808 Free PMC article.

4

An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.

Richards MW, O'Regan L, Mas-Droux C, Blot JM, Cheung J, Hoelder S, Fry AM, Bayliss R. Richards MW, et al. Mol Cell. 2009 Nov 25;36(4):560-70. doi: 10.1016/j.molcel.2009.09.038. Mol Cell. 2009. PMID: 19941817 Free PMC article.

5

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design.

Dodson CA, Kosmopoulou M, Richards MW, Atrash B, Bavetsias V, Blagg J, Bayliss R. Dodson CA, et al. Among authors: richards mw. Biochem J. 2010 Mar 15;427(1):19-28. doi: 10.1042/BJ20091530. Biochem J. 2010. PMID: 20067443

6

Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR).

Oberoi J, Richards MW, Crumpler S, Brown N, Blagg J, Bayliss R. Oberoi J, et al. Among authors: richards mw. J Biol Chem. 2010 Dec 10;285(50):39348-58. doi: 10.1074/jbc.M110.159855. Epub 2010 Sep 29. J Biol Chem. 2010. PMID: 20880844 Free PMC article.

7

Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.

Joshi A, Newbatt Y, McAndrew PC, Stubbs M, Burke R, Richards MW, Bhatia C, Caldwell JJ, McHardy T, Collins I, Bayliss R. Joshi A, et al. Among authors: richards mw. Oncotarget. 2015 May 30;6(15):13019-35. doi: 10.18632/oncotarget.3864. Oncotarget. 2015. PMID: 25968568 Free PMC article.

8

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs.

Bayliss R, Choi J, Fennell DA, Fry AM, Richards MW. Bayliss R, et al. Among authors: richards mw. Cell Mol Life Sci. 2016 Mar;73(6):1209-24. doi: 10.1007/s00018-015-2117-6. Epub 2016 Jan 11. Cell Mol Life Sci. 2016. PMID: 26755435 Free PMC article. Review.

9

A closed conformation of the Caenorhabditis elegans separase-securin complex.

Bachmann G, Richards MW, Winter A, Beuron F, Morris E, Bayliss R. Bachmann G, et al. Among authors: richards mw. Open Biol. 2016 Apr;6(4):160032. doi: 10.1098/rsob.160032. Epub 2016 Apr 13. Open Biol. 2016. PMID: 27249343 Free PMC article.

10

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.

Burgess SG, Oleksy A, Cavazza T, Richards MW, Vernos I, Matthews D, Bayliss R. Burgess SG, et al. Among authors: richards mw. Open Biol. 2016 Jul;6(7):160089. doi: 10.1098/rsob.160089. Open Biol. 2016. PMID: 27411893 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

55 results

Search Page

Filters