Hartmann RW - Search Results

1

Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection.

Murgia X, Kany AM, Herr C, Ho DK, De Rossi C, Bals R, Lehr CM, Hirsch AKH, Hartmann RW, Empting M, Röhrig T. Murgia X, et al. Among authors: hartmann rw. Sci Rep. 2020 Oct 5;10(1):16502. doi: 10.1038/s41598-020-73459-5. Sci Rep. 2020. PMID: 33020513 Free PMC article.

2

Multilayer coating of gold nanoparticles with drug-polymer coadsorbates.

Reum N, Fink-Straube C, Klein T, Hartmann RW, Lehr CM, Schneider M. Reum N, et al. Among authors: hartmann rw. Langmuir. 2010 Nov 16;26(22):16901-8. doi: 10.1021/la103109b. Epub 2010 Oct 21. Langmuir. 2010. PMID: 20964349

3

Discovery of antagonists of PqsR, a key player in 2-alkyl-4-quinolone-dependent quorum sensing in Pseudomonas aeruginosa.

Lu C, Kirsch B, Zimmer C, de Jong JC, Henn C, Maurer CK, Müsken M, Häussler S, Steinbach A, Hartmann RW. Lu C, et al. Among authors: hartmann rw. Chem Biol. 2012 Mar 23;19(3):381-90. doi: 10.1016/j.chembiol.2012.01.015. Chem Biol. 2012. PMID: 22444593

4

Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors.

Storz MP, Maurer CK, Zimmer C, Wagner N, Brengel C, de Jong JC, Lucas S, Müsken M, Häussler S, Steinbach A, Hartmann RW. Storz MP, et al. Among authors: hartmann rw. J Am Chem Soc. 2012 Oct 3;134(39):16143-6. doi: 10.1021/ja3072397. Epub 2012 Sep 24. J Am Chem Soc. 2012. PMID: 22992202

5

Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR, and molecular docking.

Weidel E, de Jong JC, Brengel C, Storz MP, Braunshausen A, Negri M, Plaza A, Steinbach A, Müller R, Hartmann RW. Weidel E, et al. Among authors: hartmann rw. J Med Chem. 2013 Aug 8;56(15):6146-55. doi: 10.1021/jm4006302. Epub 2013 Jul 19. J Med Chem. 2013. PMID: 23834469

6

Development and validation of a UHPLC-MS/MS procedure for quantification of the Pseudomonas Quinolone Signal in bacterial culture after acetylation for characterization of new quorum sensing inhibitors.

Maurer CK, Steinbach A, Hartmann RW. Maurer CK, et al. Among authors: hartmann rw. J Pharm Biomed Anal. 2013 Dec;86:127-34. doi: 10.1016/j.jpba.2013.07.047. Epub 2013 Aug 14. J Pharm Biomed Anal. 2013. PMID: 24001903

7

Combining in silico and biophysical methods for the development of Pseudomonas aeruginosa quorum sensing inhibitors: an alternative approach for structure-based drug design.

Sahner JH, Brengel C, Storz MP, Groh M, Plaza A, Müller R, Hartmann RW. Sahner JH, et al. Among authors: hartmann rw. J Med Chem. 2013 Nov 14;56(21):8656-64. doi: 10.1021/jm401102e. Epub 2013 Oct 18. J Med Chem. 2013. PMID: 24083807

8

Biochemical and biophysical analysis of a chiral PqsD inhibitor revealing tight-binding behavior and enantiomers with contrary thermodynamic signatures.

Storz MP, Brengel C, Weidel E, Hoffmann M, Hollemeyer K, Steinbach A, Müller R, Empting M, Hartmann RW. Storz MP, et al. Among authors: hartmann rw. ACS Chem Biol. 2013 Dec 20;8(12):2794-801. doi: 10.1021/cb400530d. Epub 2013 Oct 25. ACS Chem Biol. 2013. PMID: 24099650

9

Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections.

Hinsberger S, de Jong JC, Groh M, Haupenthal J, Hartmann RW. Hinsberger S, et al. Among authors: hartmann rw. Eur J Med Chem. 2014 Apr 9;76:343-51. doi: 10.1016/j.ejmech.2014.02.014. Epub 2014 Feb 11. Eur J Med Chem. 2014. PMID: 24589489

10

Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors.

Schmitt C, Kail D, Mariano M, Empting M, Weber N, Paul T, Hartmann RW, Engel M. Schmitt C, et al. Among authors: hartmann rw. PLoS One. 2014 Mar 27;9(3):e87851. doi: 10.1371/journal.pone.0087851. eCollection 2014. PLoS One. 2014. PMID: 24676346 Free PMC article.

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