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Page 1
Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study.
Darden DB, Bacher R, Brusko MA, Knight P, Hawkins RB, Cox MC, Dirain ML, Ungaro R, Nacionales DC, Rincon JC, Gauthier ML, Kladde M, Bihorac A, Brusko TM, Moore FA, Brakenridge SC, Mohr AM, Moldawer LL, Efron PA. Darden DB, et al. Among authors: dirain ml. Shock. 2021 May 1;55(5):587-595. doi: 10.1097/SHK.0000000000001671. Shock. 2021. PMID: 33021571 Free PMC article.
Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis.
Stortz JA, Murphy TJ, Raymond SL, Mira JC, Ungaro R, Dirain ML, Nacionales DC, Loftus TJ, Wang Z, Ozrazgat-Baslanti T, Ghita GL, Brumback BA, Mohr AM, Bihorac A, Efron PA, Moldawer LL, Moore FA, Brakenridge SC. Stortz JA, et al. Among authors: dirain ml. Shock. 2018 Mar;49(3):249-258. doi: 10.1097/SHK.0000000000000981. Shock. 2018. PMID: 28885387 Free PMC article. Clinical Trial.
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.
Hollen MK, Stortz JA, Darden D, Dirain ML, Nacionales DC, Hawkins RB, Cox MC, Lopez MC, Rincon JC, Ungaro R, Wang Z, Wu Q, Brumback B, Gauthier ML, Kladde M, Leeuwenburgh C, Segal M, Bihorac A, Brakenridge S, Moore FA, Baker HV, Mohr AM, Moldawer LL, Efron PA. Hollen MK, et al. Among authors: dirain ml. Crit Care. 2019 Nov 13;23(1):355. doi: 10.1186/s13054-019-2628-x. Crit Care. 2019. PMID: 31722736 Free PMC article.
Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice.
Mankowski RT, Thomas RM, Darden DB, Gharaibeh RZ, Hawkins RB, Cox MC, Apple C, Nacionales DC, Ungaro RF, Dirain ML, Moore FA, Leeuwenburgh C, Brakenridge SC, Clanton TL, Laitano O, Moldawer LL, Mohr AM, Efron PA. Mankowski RT, et al. Among authors: dirain ml. Shock. 2021 Apr 1;55(4):519-525. doi: 10.1097/SHK.0000000000001648. Shock. 2021. PMID: 32826817 Free PMC article.
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis.
Efron PA, Darden DB, Wang Z, Nacionales DC, Lopez MC, Hawkins RB, Cox MC, Rincon JC, Ungaro R, Dirain ML, Ghita GL, Chen T, Billiar TR, Delano MJ, Leeuwenburgh C, Bihorac A, Brakenridge SC, Moore FA, Mohr AM, Tompkins RG, Brumback BA, Baker HV, Upchurch GR, Moldawer LL. Efron PA, et al. Among authors: dirain ml. FASEB J. 2021 Feb;35(2):e21156. doi: 10.1096/fj.202002150R. Epub 2020 Nov 2. FASEB J. 2021. PMID: 33140449 Free PMC article.
A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis.
Darden DB, Dong X, Brusko MA, Kelly L, Fenner B, Rincon JC, Dirain ML, Ungaro R, Nacionales DC, Gauthier M, Kladde M, Brusko TM, Bihorac A, Moore FA, Loftus T, Bacher R, Moldawer LL, Mohr AM, Efron PA. Darden DB, et al. Among authors: dirain ml. Front Immunol. 2021 Aug 16;12:696536. doi: 10.3389/fimmu.2021.696536. eCollection 2021. Front Immunol. 2021. PMID: 34484194 Free PMC article.
Evaluation of a Multivalent Transcriptomic Metric for Diagnosing Surgical Sepsis and Estimating Mortality Among Critically Ill Patients.
Brakenridge SC, Chen UI, Loftus T, Ungaro R, Dirain M, Kerr A, Zhong L, Bacher R, Starostik P, Ghita G, Midic U, Darden D, Fenner B, Wacker J, Efron PA, Liesenfeld O, Sweeney TE, Moldawer LL. Brakenridge SC, et al. JAMA Netw Open. 2022 Jul 1;5(7):e2221520. doi: 10.1001/jamanetworkopen.2022.21520. JAMA Netw Open. 2022. PMID: 35819783 Free PMC article.
Sepsis is associated with reduced spontaneous neutrophil migration velocity in human adults.
Raymond SL, Hawkins RB, Stortz JA, Murphy TJ, Ungaro R, Dirain ML, Nacionales DC, Hollen MK, Rincon JC, Larson SD, Brakenridge SC, Moore FA, Irimia D, Efron PA, Moldawer LL. Raymond SL, et al. Among authors: dirain ml. PLoS One. 2018 Oct 9;13(10):e0205327. doi: 10.1371/journal.pone.0205327. eCollection 2018. PLoS One. 2018. PMID: 30300408 Free PMC article.
Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.
Stortz JA, Hollen MK, Nacionales DC, Horiguchi H, Ungaro R, Dirain ML, Wang Z, Wu Q, Wu KK, Kumar A, Foster TC, Stewart BD, Ross JA, Segal M, Bihorac A, Brakenridge S, Moore FA, Wohlgemuth SE, Leeuwenburgh C, Mohr AM, Moldawer LL, Efron PA. Stortz JA, et al. Among authors: dirain ml. Crit Care Med. 2019 Nov;47(11):e919-e929. doi: 10.1097/CCM.0000000000003926. Crit Care Med. 2019. PMID: 31389840 Free PMC article.
35 results