Liang X - Search Results

1

In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation.

Liang X, Park Y, DeForest N, Hao J, Zhao X, Niu C, Wang K, Smith B, Lai Y. Liang X, et al. Drug Metab Dispos. 2020 Dec;48(12):1283-1292. doi: 10.1124/dmd.120.000163. Epub 2020 Oct 9. Drug Metab Dispos. 2020. PMID: 33037043

2

Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).

Liang X, Chien HC, Yee SW, Giacomini MM, Chen EC, Piao M, Hao J, Twelves J, Lepist EI, Ray AS, Giacomini KM. Liang X, et al. Mol Pharm. 2015 Dec 7;12(12):4301-10. doi: 10.1021/acs.molpharmaceut.5b00501. Epub 2015 Nov 16. Mol Pharm. 2015. PMID: 26528626 Free PMC article.

3

Interaction of 2,4-Diaminopyrimidine-Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters.

Giacomini MM, Hao J, Liang X, Chandrasekhar J, Twelves J, Whitney JA, Lepist EI, Ray AS. Giacomini MM, et al. Among authors: liang x. Drug Metab Dispos. 2017 Jan;45(1):76-85. doi: 10.1124/dmd.116.073338. Epub 2016 Nov 1. Drug Metab Dispos. 2017. PMID: 27803021

4

In Vivo Hepatic Enhancer Elements in the Human ABCG2 Locus.

Eclov RJ, Kim MJ, Smith RP, Liang X, Ahituv N, Kroetz DL. Eclov RJ, et al. Among authors: liang x. Drug Metab Dispos. 2017 Feb;45(2):208-215. doi: 10.1124/dmd.116.072033. Epub 2016 Nov 17. Drug Metab Dispos. 2017. PMID: 27856528 Free PMC article.

5

Overcoming the shortcomings of the extended-clearance concept: a framework for developing a physiologically-based pharmacokinetic (PBPK) model to select drug candidates involving transporter-mediated clearance.

Liang X, Lai Y. Liang X, et al. Expert Opin Drug Metab Toxicol. 2021 Aug;17(8):869-886. doi: 10.1080/17425255.2021.1912012. Epub 2021 Jun 15. Expert Opin Drug Metab Toxicol. 2021. PMID: 33793347 Review.

6

Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys.

Cheng Y, Liang X, Hao J, Niu C, Lai Y. Cheng Y, et al. Among authors: liang x. Clin Transl Sci. 2021 Sep;14(5):1924-1934. doi: 10.1111/cts.13047. Epub 2021 May 31. Clin Transl Sci. 2021. PMID: 34058067 Free PMC article.

7

The next frontier in ADME science: Predicting transporter-based drug disposition, tissue concentrations and drug-drug interactions in humans.

Storelli F, Yin M, Kumar AR, Ladumor MK, Evers R, Chothe PP, Enogieru OJ, Liang X, Lai Y, Unadkat JD. Storelli F, et al. Among authors: liang x. Pharmacol Ther. 2022 Oct;238:108271. doi: 10.1016/j.pharmthera.2022.108271. Epub 2022 Aug 21. Pharmacol Ther. 2022. PMID: 36002079 Review.

8

Predicting changes in the pharmacokinetics of CYP3A-metabolized drugs in hepatic impairment and insights into factors driving these changes.

Ladumor MK, Storelli F, Liang X, Lai Y, Enogieru OJ, Chothe PP, Evers R, Unadkat JD. Ladumor MK, et al. Among authors: liang x. CPT Pharmacometrics Syst Pharmacol. 2023 Feb;12(2):261-273. doi: 10.1002/psp4.12901. Epub 2022 Dec 20. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 36540952 Free PMC article.

9

Interpretation of Protein-Mediated Uptake of Statins by Hepatocytes Is Confounded by the Residual Statin-Protein Complex.

Yin M, Ishida K, Liang X, Lai Y, Unadkat JD. Yin M, et al. Among authors: liang x. Drug Metab Dispos. 2023 Oct;51(10):1381-1390. doi: 10.1124/dmd.123.001386. Epub 2023 Jul 10. Drug Metab Dispos. 2023. PMID: 37429727

10

Toward improved predictions of pharmacokinetics of transported drugs in hepatic impairment: Insights from the extended clearance model.

Storelli F, Ladumor MK, Liang X, Lai Y, Chothe PP, Enogieru OJ, Evers R, Unadkat JD. Storelli F, et al. Among authors: liang x. CPT Pharmacometrics Syst Pharmacol. 2024 Jan;13(1):118-131. doi: 10.1002/psp4.13062. Epub 2023 Oct 20. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 37833845 Free PMC article.

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