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The Dihydroquinolizinone Compound RG7834 Inhibits the Polyadenylase Function of PAPD5 and PAPD7 and Accelerates the Degradation of Matured Hepatitis B Virus Surface Protein mRNA.
Sun L, Zhang F, Guo F, Liu F, Kulsuptrakul J, Puschnik A, Gao M, Rijnbrand R, Sofia M, Block T, Zhou T. Sun L, et al. Among authors: block t. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e00640-20. doi: 10.1128/AAC.00640-20. Print 2020 Dec 16. Antimicrob Agents Chemother. 2020. PMID: 33046485 Free PMC article.
HBsAg mRNA degradation induced by a dihydroquinolizinone compound depends on the HBV posttranscriptional regulatory element.
Zhou T, Block T, Liu F, Kondratowicz AS, Sun L, Rawat S, Branson J, Guo F, Steuer HM, Liang H, Bailey L, Moore C, Wang X, Cuconatti A, Gao M, Lee ACH, Harasym T, Chiu T, Gotchev D, Dorsey B, Rijnbrand R, Sofia MJ. Zhou T, et al. Among authors: block t. Antiviral Res. 2018 Jan;149:191-201. doi: 10.1016/j.antiviral.2017.11.009. Epub 2017 Nov 10. Antiviral Res. 2018. PMID: 29133129
Host RNA quality control as a hepatitis B antiviral target.
Block TM, Young JAT, Javanbakht H, Sofia MJ, Zhou T. Block TM, et al. Antiviral Res. 2021 Feb;186:104972. doi: 10.1016/j.antiviral.2020.104972. Epub 2020 Nov 24. Antiviral Res. 2021. PMID: 33242518 Review.
Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2.
Zhao X, Guo F, Comunale MA, Mehta A, Sehgal M, Jain P, Cuconati A, Lin H, Block TM, Chang J, Guo JT. Zhao X, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):206-16. doi: 10.1128/AAC.03999-14. Epub 2014 Oct 27. Antimicrob Agents Chemother. 2015. PMID: 25348530 Free PMC article.
Hepatoselective Dihydroquinolizinone Bis-acids for HBsAg mRNA Degradation.
Hwang N, Sun L, Noe D, Lam PYS, Zhou T, Block TM, Du Y. Hwang N, et al. Among authors: block tm. ACS Med Chem Lett. 2021 Jun 22;12(7):1130-1136. doi: 10.1021/acsmedchemlett.1c00228. eCollection 2021 Jul 8. ACS Med Chem Lett. 2021. PMID: 34267883 Free PMC article.
478 results