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Metformin inhibits the inflammatory and oxidative stress response induced by skin UVB-irradiation and provides 4-hydroxy-2-nonenal and nitrotyrosine formation and p53 protein activation.
Souza-Neto FP, Marinello PC, Melo GP, Ramalho LZN, Cela EM, Campo VE, González-Maglio DH, Cecchini R, Cecchini AL. Souza-Neto FP, et al. J Dermatol Sci. 2020 Nov;100(2):152-155. doi: 10.1016/j.jdermsci.2020.05.012. Epub 2020 Jun 2. J Dermatol Sci. 2020. PMID: 33051086 No abstract available.
Therapeutic treatment with phosphodiesterase-4 inhibitors alleviates kidney injury and renal fibrosis by increasing MMP-9 in a doxorubicin-induced nephrotoxicity mouse model.
Costa WC, Beltrami VA, Campolina-Silva GH, Queiroz-Junior CM, Florentino RM, Machado JR, Martins DG, Gonçalves WA, Barroso LC, Freitas KM, de Souza-Neto FP, Félix FB, da Silva RF, Oliveira CA, Câmara NOS, Rachid MA, Teixeira MM, Rezende BM, Pinho V. Costa WC, et al. Among authors: de souza neto fp. Int Immunopharmacol. 2023 Feb;115:109583. doi: 10.1016/j.intimp.2022.109583. Epub 2023 Jan 5. Int Immunopharmacol. 2023. PMID: 36610330
Increased cholinergic activity under conditions of low estrogen leads to adverse cardiac remodeling.
Teixeira VP, Miranda K, Scalzo S, Rocha-Resende C, Silva MM, Tezini GCSV, Melo MB, Souza-Neto FP, Silva KSC, Jesus ICG, Santos AK, de Oliveira M, Szawka RE, Salgado HC, Prado MAM, Poletini MO, Guatimosim S. Teixeira VP, et al. Among authors: souza neto fp. Am J Physiol Cell Physiol. 2021 Apr 1;320(4):C602-C612. doi: 10.1152/ajpcell.00142.2020. Epub 2020 Dec 9. Am J Physiol Cell Physiol. 2021. PMID: 33296286 Free article.
Alamandine improves cardiac remodeling induced by transverse aortic constriction in mice.
Silva MM, de Souza-Neto FP, Jesus ICG, Gonçalves GK, Santuchi MC, Sanches BL, de Alcântara-Leonídio TC, Melo MB, Vieira MAR, Guatimosim S, Santos RAS, da Silva RF. Silva MM, et al. Among authors: de souza neto fp. Am J Physiol Heart Circ Physiol. 2021 Jan 1;320(1):H352-H363. doi: 10.1152/ajpheart.00328.2020. Epub 2020 Oct 30. Am J Physiol Heart Circ Physiol. 2021. PMID: 33124885 Free article.
Quercetin increases bioavailability of nitric oxide in the jejunum of euglycemic and diabetic rats and induces neuronal plasticity in the myenteric plexus.
Martins-Perles JVC, Bossolani GDP, Zignani I, de Souza SRG, Frez FCV, de Souza Melo CG, Barili E, de Souza Neto FP, Guarnier FA, Armani ALC, Cecchini R, Zanoni JN. Martins-Perles JVC, et al. Among authors: de souza neto fp. Auton Neurosci. 2020 Sep;227:102675. doi: 10.1016/j.autneu.2020.102675. Epub 2020 May 6. Auton Neurosci. 2020. PMID: 32474374
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