Lu L - Search Results

1

Griffithsin with A Broad-Spectrum Antiviral Activity by Binding Glycans in Viral Glycoprotein Exhibits Strong Synergistic Effect in Combination with A Pan-Coronavirus Fusion Inhibitor Targeting SARS-CoV-2 Spike S2 Subunit.

Cai Y, Xu W, Gu C, Cai X, Qu D, Lu L, Xie Y, Jiang S. Cai Y, et al. Among authors: lu l. Virol Sin. 2020 Dec;35(6):857-860. doi: 10.1007/s12250-020-00305-3. Epub 2020 Oct 14. Virol Sin. 2020. PMID: 33052520 Free PMC article. No abstract available.

2

Novel recombinant engineered gp41 N-terminal heptad repeat trimers and their potential as anti-HIV-1 therapeutics or microbicides.

Chen X, Lu L, Qi Z, Lu H, Wang J, Yu X, Chen Y, Jiang S. Chen X, et al. Among authors: lu h, lu l. J Biol Chem. 2010 Aug 13;285(33):25506-15. doi: 10.1074/jbc.M110.101170. Epub 2010 Jun 10. J Biol Chem. 2010. PMID: 20538590 Free PMC article.

3

Combinations of 3-hydroxyphthalic anhydride-modified ovalbumin with antiretroviral drug-based microbicide candidates display synergistic and complementary effects against HIV-1 infection.

Li L, Tan S, Lu H, Lu L, Yang J, Jin H, Liu S, Jiang S. Li L, et al. Among authors: lu h, lu l. J Acquir Immune Defic Syndr. 2011 Apr 15;56(5):384-92. doi: 10.1097/QAI.0b013e31820a4a8d. J Acquir Immune Defic Syndr. 2011. PMID: 21239999 Free PMC article.

4

HIV-1 gp41 core with exposed membrane-proximal external region inducing broad HIV-1 neutralizing antibodies.

Wang J, Tong P, Lu L, Zhou L, Xu L, Jiang S, Chen YH. Wang J, et al. Among authors: lu l. PLoS One. 2011 Mar 31;6(3):e18233. doi: 10.1371/journal.pone.0018233. PLoS One. 2011. PMID: 21483871 Free PMC article.

5

A novel chimeric protein-based HIV-1 fusion inhibitor targeting gp41 glycoprotein with high potency and stability.

Pan C, Cai L, Lu H, Lu L, Jiang S. Pan C, et al. Among authors: lu h, lu l. J Biol Chem. 2011 Aug 12;286(32):28425-34. doi: 10.1074/jbc.M111.241992. Epub 2011 Jun 20. J Biol Chem. 2011. PMID: 21690094 Free PMC article.

6

Mutations of Gln64 in the HIV-1 gp41 N-terminal heptad repeat render viruses resistant to peptide HIV fusion inhibitors targeting the gp41 pocket.

Yu X, Lu L, Cai L, Tong P, Tan S, Zou P, Meng F, Chen YH, Jiang S. Yu X, et al. Among authors: lu l. J Virol. 2012 Jan;86(1):589-93. doi: 10.1128/JVI.05066-11. Epub 2011 Oct 19. J Virol. 2012. PMID: 22013063 Free PMC article.

7

HIV-1 glycoprotein 41 ectodomain induces activation of the CD74 protein-mediated extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to enhance viral infection.

Zhou C, Lu L, Tan S, Jiang S, Chen YH. Zhou C, et al. Among authors: lu l. J Biol Chem. 2011 Dec 30;286(52):44869-77. doi: 10.1074/jbc.M111.267393. Epub 2011 Oct 28. J Biol Chem. 2011. PMID: 22039051 Free PMC article.

8

Design, synthesis, and biological activity of novel 1,4-disubstituted piperidine/piperazine derivatives as CCR5 antagonist-based HIV-1 entry inhibitors.

Dong MX, Lu L, Li H, Wang X, Lu H, Jiang S, Dai QY. Dong MX, et al. Among authors: lu h, lu l. Bioorg Med Chem Lett. 2012 May 1;22(9):3284-6. doi: 10.1016/j.bmcl.2012.03.019. Epub 2012 Mar 11. Bioorg Med Chem Lett. 2012. PMID: 22464131

9

HIV-1 variants with a single-point mutation in the gp41 pocket region exhibiting different susceptibility to HIV fusion inhibitors with pocket- or membrane-binding domain.

Lu L, Tong P, Yu X, Pan C, Zou P, Chen YH, Jiang S. Lu L, et al. Biochim Biophys Acta. 2012 Dec;1818(12):2950-7. doi: 10.1016/j.bbamem.2012.07.020. Epub 2012 Jul 31. Biochim Biophys Acta. 2012. PMID: 22867851 Free article.

10

The conserved residue Arg46 in the N-terminal heptad repeat domain of HIV-1 gp41 is critical for viral fusion and entry.

Wang X, Xiong W, Ma X, Wei M, Chen Y, Lu L, Debnath AK, Jiang S, Pan C. Wang X, et al. Among authors: lu l. PLoS One. 2012;7(9):e44874. doi: 10.1371/journal.pone.0044874. Epub 2012 Sep 7. PLoS One. 2012. PMID: 22970321 Free PMC article.

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