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Page 1
Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format.
Mannhardt I, Saleem U, Mosqueira D, Loos MF, Ulmer BM, Lemoine MD, Larsson C, Améen C, de Korte T, Vlaming MLH, Harris K, Clements P, Denning C, Hansen A, Eschenhagen T. Mannhardt I, et al. Among authors: clements p. Stem Cell Reports. 2020 Oct 13;15(4):983-998. doi: 10.1016/j.stemcr.2020.09.002. Stem Cell Reports. 2020. PMID: 33053362 Free PMC article.
Unlocking Personalized Biomedicine and Drug Discovery with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Fit for Purpose or Forever Elusive?
de Korte T, Katili PA, Mohd Yusof NAN, van Meer BJ, Saleem U, Burton FL, Smith GL, Clements P, Mummery CL, Eschenhagen T, Hansen A, Denning C. de Korte T, et al. Among authors: clements p. Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:529-551. doi: 10.1146/annurev-pharmtox-010919-023309. Epub 2019 Sep 10. Annu Rev Pharmacol Toxicol. 2020. PMID: 31506008 Review.
Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes.
Saleem U, van Meer BJ, Katili PA, Mohd Yusof NAN, Mannhardt I, Garcia AK, Tertoolen L, de Korte T, Vlaming MLH, McGlynn K, Nebel J, Bahinski A, Harris K, Rossman E, Xu X, Burton FL, Smith GL, Clements P, Mummery CL, Eschenhagen T, Hansen A, Denning C. Saleem U, et al. Among authors: clements p. Toxicol Sci. 2020 Jul 1;176(1):103-123. doi: 10.1093/toxsci/kfaa058. Toxicol Sci. 2020. PMID: 32421822 Free PMC article.
Evaluating Associations Between Nonclinical Cardiovascular Functional Endpoints and Repeat-dose Cardiovascular Toxicity in the Beagle Dog: A Cross-company Initiative.
Milliken P, Aylott M, Edmunds N, Engle S, Ewart L, Fleurance R, Guffroy M, Hargreaves A, Heinz-Taheny K, Kirk S, Leishman D, Leong L, McMahon N, Valentin JP, Watson D, Wallis R, Clements P. Milliken P, et al. Among authors: clements p. Toxicol Sci. 2020 Jul 1;176(1):224-235. doi: 10.1093/toxsci/kfaa051. Toxicol Sci. 2020. PMID: 32298455
Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury.
Cross MJ, Berridge BR, Clements PJ, Cove-Smith L, Force TL, Hoffmann P, Holbrook M, Lyon AR, Mellor HR, Norris AA, Pirmohamed M, Tugwood JD, Sidaway JE, Park BK. Cross MJ, et al. Among authors: clements pj. Br J Pharmacol. 2015 Feb;172(4):957-74. doi: 10.1111/bph.12979. Epub 2015 Jan 12. Br J Pharmacol. 2015. PMID: 25302413 Free PMC article. Review.
Information-Derived Mechanistic Hypotheses for Structural Cardiotoxicity.
Svensson F, Zoufir A, Mahmoud S, Afzal AM, Smit I, Giblin KA, Clements PJ, Mettetal JT, Pointon A, Harvey JS, Greene N, Williams RV, Bender A. Svensson F, et al. Chem Res Toxicol. 2018 Nov 19;31(11):1119-1127. doi: 10.1021/acs.chemrestox.8b00159. Epub 2018 Oct 17. Chem Res Toxicol. 2018. PMID: 30350600
418 results