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Page 1
Brain Penetrable Inhibitors of Ceramide Galactosyltransferase for the Treatment of Lysosomal Storage Disorders.
Thurairatnam S, Lim S, Barker RH Jr, Choi-Sledeski YM, Hirth BH, Jiang J, Macor JE, Makino E, Maniar S, Musick K, Pribish JR, Munson M. Thurairatnam S, et al. Among authors: choi sledeski ym. ACS Med Chem Lett. 2020 Jun 16;11(10):2010-2016. doi: 10.1021/acsmedchemlett.0c00120. eCollection 2020 Oct 8. ACS Med Chem Lett. 2020. PMID: 33062186 Free PMC article.
Sulfonamidopyrrolidinone factor Xa inhibitors: potency and selectivity enhancements via P-1 and P-4 optimization.
Choi-Sledeski YM, McGarry DG, Green DM, Mason HJ, Becker MR, Davis RS, Ewing WR, Dankulich WP, Manetta VE, Morris RL, Spada AP, Cheney DL, Brown KD, Colussi DJ, Chu V, Heran CL, Morgan SR, Bentley RG, Leadley RJ, Maignan S, Guilloteau JP, Dunwiddie CT, Pauls HW. Choi-Sledeski YM, et al. J Med Chem. 1999 Sep 9;42(18):3572-87. doi: 10.1021/jm990041+. J Med Chem. 1999. PMID: 10479289
Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa.
Ewing WR, Becker MR, Manetta VE, Davis RS, Pauls HW, Mason H, Choi-Sledeski YM, Green D, Cha D, Spada AP, Cheney DL, Mason JS, Maignan S, Guilloteau JP, Brown K, Colussi D, Bentley R, Bostwick J, Kasiewski CJ, Morgan SR, Leadley RJ, Dunwiddie CT, Perrone MH, Chu V. Ewing WR, et al. J Med Chem. 1999 Sep 9;42(18):3557-71. doi: 10.1021/jm990040h. J Med Chem. 1999. PMID: 10479288
A conformationally constrained inhibitor with an enhanced potency for β-tryptase and stability against semicarbazide-sensitive amine oxidase (SSAO).
Liang G, Choi-Sledeski YM, Poli G, Chen X, Shum P, Minnich A, Wang Q, Tsay J, Sides K, Cairns J, Stoklosa G, Nieduzak T, Zhao Z, Wang J, Vaz RJ. Liang G, et al. Among authors: choi sledeski ym. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6721-4. doi: 10.1016/j.bmcl.2010.08.141. Epub 2010 Sep 6. Bioorg Med Chem Lett. 2010. PMID: 20855210
Discovery of an orally efficacious inhibitor of coagulation factor Xa which incorporates a neutral P1 ligand.
Choi-Sledeski YM, Kearney R, Poli G, Pauls H, Gardner C, Gong Y, Becker M, Davis R, Spada A, Liang G, Chu V, Brown K, Collussi D, Leadley R Jr, Rebello S, Moxey P, Morgan S, Bentley R, Kasiewski C, Maignan S, Guilloteau JP, Mikol V. Choi-Sledeski YM, et al. J Med Chem. 2003 Feb 27;46(5):681-4. doi: 10.1021/jm020384z. J Med Chem. 2003. PMID: 12593648
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