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Negative allosteric modulation of alpha 5-containing GABAA receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice.
Xu NZ, Ernst M, Treven M, Cerne R, Wakulchik M, Li X, Jones TM, Gleason SD, Morrow D, Schkeryantz JM, Rahman MT, Li G, Poe MM, Cook JM, Witkin JM. Xu NZ, et al. Among authors: li g, li x. Psychopharmacology (Berl). 2018 Apr;235(4):1151-1161. doi: 10.1007/s00213-018-4832-9. Epub 2018 Jan 26. Psychopharmacology (Berl). 2018. PMID: 29374303
Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles.
Prevot TD, Li G, Vidojevic A, Misquitta KA, Fee C, Santrac A, Knutson DE, Stephen MR, Kodali R, Zahn NM, Arnold LA, Scholze P, Fisher JL, Marković BD, Banasr M, Cook JM, Savic M, Sibille E. Prevot TD, et al. Among authors: li g. Mol Neuropsychiatry. 2019 Apr;5(2):84-97. doi: 10.1159/000496086. Epub 2019 Jan 23. Mol Neuropsychiatry. 2019. PMID: 31192221 Free PMC article.
Synthesis of chiral GABAA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression.
Li G, Stephen MR, Kodali R, Zahn NM, Poe MM, Tiruveedhula VVNPB, Huber AT, Schussman MK, Qualmann K, Panhans CM, Raddatz NJ, Baker DA, Prevot TD, Banasr M, Sibille E, Arnold LA, Cook JM. Li G, et al. ARKIVOC. 2018;2018(4):158-182. doi: 10.24820/ark.5550190.p010.460. Epub 2018 Mar 11. ARKIVOC. 2018. PMID: 32774192 Free PMC article.
Distinct sex-dependent behavioral responses induced by two positive allosteric modulators of alpha 5 subunit-containing GABAA receptors.
Souza AJ, Cortez IL, Silva NR, Pedrazzi JFC, Domingos LB, Braga MS, Santos-Silva T, Del-Bel EA, Resstel LBM, Li G, Mian MY, Sharmin D, Guimarães FS, Cook JM, Gomes FV. Souza AJ, et al. Among authors: li g. Behav Brain Res. 2022 Jun 25;428:113832. doi: 10.1016/j.bbr.2022.113832. Epub 2022 Mar 5. Behav Brain Res. 2022. PMID: 35259414
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