Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation.
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J Immunother Cancer. 2023 Jan;11(1):e005871. doi: 10.1136/jitc-2022-005871.
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PMID: 36639156
Free PMC article.