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Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists.
Konecny J, Misiachna A, Hrabinova M, Pulkrabkova L, Benkova M, Prchal L, Kucera T, Kobrlova T, Finger V, Kolcheva M, Kortus S, Jun D, Valko M, Horak M, Soukup O, Korabecny J. Konecny J, et al. Among authors: kortus s. Biomolecules. 2020 Dec 22;11(1):3. doi: 10.3390/biom11010003. Biomolecules. 2020. PMID: 33375115 Free PMC article.
Specific pathogenic mutations in the M3 domain of the GluN1 subunit regulate the surface delivery and pharmacological sensitivity of NMDA receptors.
Kolcheva M, Kortus S, Krausova BH, Barackova P, Misiachna A, Danacikova S, Kaniakova M, Hemelikova K, Hotovec M, Rehakova K, Horak M. Kolcheva M, et al. Among authors: kortus s. Neuropharmacology. 2021 May 15;189:108528. doi: 10.1016/j.neuropharm.2021.108528. Epub 2021 Mar 25. Neuropharmacology. 2021. PMID: 33773999
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors.
Gorecki L, Misiachna A, Damborsky J, Dolezal R, Korabecny J, Cejkova L, Hakenova K, Chvojkova M, Karasova JZ, Prchal L, Novak M, Kolcheva M, Kortus S, Vales K, Horak M, Soukup O. Gorecki L, et al. Among authors: kortus s. Eur J Med Chem. 2021 Jul 5;219:113434. doi: 10.1016/j.ejmech.2021.113434. Epub 2021 Apr 20. Eur J Med Chem. 2021. PMID: 33892271 Free article.
The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors.
Kolcheva M, Ladislav M, Netolicky J, Kortus S, Rehakova K, Krausova BH, Hemelikova K, Misiachna A, Kadkova A, Klima M, Chalupska D, Horak M. Kolcheva M, et al. Among authors: kortus s. Neuropharmacology. 2023 Jan 1;222:109297. doi: 10.1016/j.neuropharm.2022.109297. Epub 2022 Nov 1. Neuropharmacology. 2023. PMID: 36341805 Free article.
Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes.
Kortus S, Rehakova K, Klima M, Kolcheva M, Ladislav M, Langore E, Barackova P, Netolicky J, Misiachna A, Hemelikova K, Humpolickova J, Chalupska D, Silhan J, Kaniakova M, Hrcka Krausova B, Boura E, Zapotocky M, Horak M. Kortus S, et al. J Neurosci. 2023 Jun 28;43(26):4755-4774. doi: 10.1523/JNEUROSCI.2014-22.2023. Epub 2023 Jun 7. J Neurosci. 2023. PMID: 37286354 Free PMC article.
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