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Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo.
Mugnaini C, Brizzi A, Paolino M, Scarselli E, Castelli R, de Candia M, Gambacorta N, Nicolotti O, Kostrzewa M, Kumar P, Mahmoud AM, Borgonetti V, Iannotta M, Morace A, Galeotti N, Maione S, Altomare CD, Ligresti A, Corelli F. Mugnaini C, et al. ACS Chem Neurosci. 2024 Mar 6;15(5):955-971. doi: 10.1021/acschemneuro.3c00656. Epub 2024 Feb 19. ACS Chem Neurosci. 2024. PMID: 38372253
Anorectic effect of COR659 in a rat model of overeating.
Maccioni P, Mugnaini C, Carai MAM, Gessa GL, Corelli F, Colombo G. Maccioni P, et al. Among authors: mugnaini c. Behav Pharmacol. 2023 Oct 1;34(7):437-442. doi: 10.1097/FBP.0000000000000751. Epub 2023 Aug 31. Behav Pharmacol. 2023. PMID: 37712580
Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor.
Mugnaini C, Kostrzewa M, Casini M, Kumar P, Catallo V, Allarà M, Guastaferro L, Brizzi A, Paolino M, Tafi A, Kapatais C, Giorgi G, Vacondio F, Mor M, Corelli F, Ligresti A. Mugnaini C, et al. Molecules. 2023 Jun 24;28(13):4958. doi: 10.3390/molecules28134958. Molecules. 2023. PMID: 37446625 Free PMC article.
In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists.
Romeo I, Brizzi A, Pessina F, Ambrosio FA, Aiello F, Belardo C, Carullo G, Costa G, De Petrocellis L, Frosini M, Luongo L, Maramai S, Paolino M, Moriello AS, Mugnaini C, Scorzelli F, Maione S, Corelli F, Di Marzo V, Alcaro S, Artese A. Romeo I, et al. Among authors: mugnaini c. J Med Chem. 2023 May 25;66(10):6994-7015. doi: 10.1021/acs.jmedchem.3c00447. Epub 2023 May 16. J Med Chem. 2023. PMID: 37192374
84 results