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Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.
Eysert F, Coulon A, Boscher E, Vreulx AC, Flaig A, Mendes T, Hughes S, Grenier-Boley B, Hanoulle X, Demiautte F, Bauer C, Marttinen M, Takalo M, Amouyel P, Desai S, Pike I, Hiltunen M, Chécler F, Farinelli M, Delay C, Malmanche N, Hébert SS, Dumont J, Kilinc D, Lambert JC, Chapuis J. Eysert F, et al. Among authors: checler f. Mol Psychiatry. 2021 Oct;26(10):5592-5607. doi: 10.1038/s41380-020-00926-w. Epub 2020 Nov 3. Mol Psychiatry. 2021. PMID: 33144711 Free PMC article.
The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein.
Cissé M, Duplan E, Guillot-Sestier MV, Rumigny J, Bauer C, Pagès G, Orzechowski HD, Slack BE, Checler F, Vincent B. Cissé M, et al. Among authors: checler f. J Biol Chem. 2011 Aug 19;286(33):29192-29206. doi: 10.1074/jbc.M110.208249. Epub 2011 May 17. J Biol Chem. 2011. PMID: 21586567 Free PMC article.
Study on Aβ34 biology and detection in transgenic mice brains.
Caillava C, Ranaldi S, Lauritzen I, Bauer C, Fareh J, Abraham JD, Checler F. Caillava C, et al. Among authors: checler f. Neurobiol Aging. 2014 Jul;35(7):1570-81. doi: 10.1016/j.neurobiolaging.2014.01.011. Epub 2014 Jan 11. Neurobiol Aging. 2014. PMID: 24495834
MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.
Baranger K, Marchalant Y, Bonnet AE, Crouzin N, Carrete A, Paumier JM, Py NA, Bernard A, Bauer C, Charrat E, Moschke K, Seiki M, Vignes M, Lichtenthaler SF, Checler F, Khrestchatisky M, Rivera S. Baranger K, et al. Among authors: checler f. Cell Mol Life Sci. 2016 Jan;73(1):217-36. doi: 10.1007/s00018-015-1992-1. Epub 2015 Jul 23. Cell Mol Life Sci. 2016. PMID: 26202697 Free PMC article.
278 results