Tompson DJ - Search Results

1

Comparison of the Pharmacokinetics of RIPK1 Inhibitor GSK2982772 in Healthy Western and Japanese Subjects.

Tompson DJ, Davies C, Scott NE, Cannons EP, Kostapanos M, Gross AS, Powell M, Ino H, Shimamura R, Ogura H, Nagakubo T, Igarashi H, Nakano A. Tompson DJ, et al. Eur J Drug Metab Pharmacokinet. 2021 Jan;46(1):71-83. doi: 10.1007/s13318-020-00652-2. Eur J Drug Metab Pharmacokinet. 2021. PMID: 33165774 Free PMC article. Clinical Trial.

2

A randomised, placebo-controlled study of RIPK1 inhibitor GSK2982772 in patients with active ulcerative colitis.

Weisel K, Scott N, Berger S, Wang S, Brown K, Powell M, Broer M, Watts C, Tompson DJ, Burriss SW, Hawkins S, Abbott-Banner K, Tak PP. Weisel K, et al. Among authors: tompson dj. BMJ Open Gastroenterol. 2021 Aug;8(1):e000680. doi: 10.1136/bmjgast-2021-000680. BMJ Open Gastroenterol. 2021. PMID: 34389633 Free PMC article. Clinical Trial.

3

Single and Multiple Dose Pharmacokinetics, Pharmacodynamics and Safety of the Novel Lipoprotein-Associated Phospholipase A2 Enzyme Inhibitor Darapladib in Healthy Chinese Subjects: An Open Label Phase-1 Clinical Trial.

Hu C, Tompson D, Magee M, Chen Q, Liu YM, Zhu W, Zhao H, Gross AS, Liu Y. Hu C, et al. PLoS One. 2015 Oct 14;10(10):e0139862. doi: 10.1371/journal.pone.0139862. eCollection 2015. PLoS One. 2015. PMID: 26465780 Free PMC article. Clinical Trial.

4

Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers.

Weisel K, Scott NE, Tompson DJ, Votta BJ, Madhavan S, Povey K, Wolstenholme A, Simeoni M, Rudo T, Richards-Peterson L, Sahota T, Wang JG, Lich J, Finger J, Verticelli A, Reilly M, Gough PJ, Harris PA, Bertin J, Wang ML. Weisel K, et al. Among authors: tompson dj. Pharmacol Res Perspect. 2017 Dec;5(6):e00365. doi: 10.1002/prp2.365. Pharmacol Res Perspect. 2017. PMID: 29226626 Free PMC article. Clinical Trial.

5

Development of a Prototype, Once-Daily, Modified-Release Formulation for the Short Half-Life RIPK1 Inhibitor GSK2982772.

Tompson DJ, Whitaker M, Pan R, Johnson G, Fuller T, McKenzie L, Zann V, Powell M, Abbott-Banner K, Hawkins S. Tompson DJ, et al. Pharm Res. 2021 Jul;38(7):1235-1245. doi: 10.1007/s11095-021-03059-z. Epub 2021 Jun 16. Pharm Res. 2021. PMID: 34136987 Free PMC article. Clinical Trial.

6

Development of a Once-Daily Modified-Release Formulation for the Short Half-Life RIPK1 Inhibitor GSK2982772 using DiffCORE Technology.

Tompson D, Whitaker M, Pan R, Johnson G, Fuller T, Zann V, McKenzie L, Abbott-Banner K, Hawkins S, Powell M. Tompson D, et al. Pharm Res. 2022 Jan;39(1):153-165. doi: 10.1007/s11095-021-03124-7. Epub 2022 Jan 5. Pharm Res. 2022. PMID: 34988780 Free PMC article.

7

Response to Inhibition of Receptor-Interacting Protein Kinase 1 (RIPK1) in Active Plaque Psoriasis: A Randomized Placebo-Controlled Study.

Weisel K, Berger S, Papp K, Maari C, Krueger JG, Scott N, Tompson D, Wang S, Simeoni M, Bertin J, Peter Tak P. Weisel K, et al. Clin Pharmacol Ther. 2020 Oct;108(4):808-816. doi: 10.1002/cpt.1852. Epub 2020 Jul 7. Clin Pharmacol Ther. 2020. PMID: 32301501 Free PMC article. Clinical Trial.

8

A randomized, placebo-controlled experimental medicine study of RIPK1 inhibitor GSK2982772 in patients with moderate to severe rheumatoid arthritis.

Weisel K, Berger S, Thorn K, Taylor PC, Peterfy C, Siddall H, Tompson D, Wang S, Quattrocchi E, Burriss SW, Walter J, Tak PP. Weisel K, et al. Arthritis Res Ther. 2021 Mar 16;23(1):85. doi: 10.1186/s13075-021-02468-0. Arthritis Res Ther. 2021. PMID: 33726834 Free PMC article. Clinical Trial.

9

Efficacy and tolerability exposure-response relationship of retigabine (ezogabine) immediate-release tablets in patients with partial-onset seizures.

Tompson DJ, Crean CS, Reeve R, Berry NS. Tompson DJ, et al. Clin Ther. 2013 Aug;35(8):1174-1185.e4. doi: 10.1016/j.clinthera.2013.06.012. Epub 2013 Aug 1. Clin Ther. 2013. PMID: 23916044 Clinical Trial.

10

Lack of effect of ezogabine/retigabine on the pharmacokinetics of digoxin in healthy individuals: results from a drug-drug interaction study.

Tompson DJ, Crean CS, Buraglio M, Arumugham T. Tompson DJ, et al. Clin Pharmacol. 2014 Oct 13;6:149-59. doi: 10.2147/CPAA.S64131. eCollection 2014. Clin Pharmacol. 2014. PMID: 25342921 Free PMC article.

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