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Page 1
The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis.
Kobayashi H, Gieniec KA, Wright JA, Wang T, Asai N, Mizutani Y, Lida T, Ando R, Suzuki N, Lannagan TRM, Ng JQ, Hara A, Shiraki Y, Mii S, Ichinose M, Vrbanac L, Lawrence MJ, Sammour T, Uehara K, Davies G, Lisowski L, Alexander IE, Hayakawa Y, Butler LM, Zannettino ACW, Din MO, Hasty J, Burt AD, Leedham SJ, Rustgi AK, Mukherjee S, Wang TC, Enomoto A, Takahashi M, Worthley DL, Woods SL. Kobayashi H, et al. Among authors: leedham sj. Gastroenterology. 2021 Mar;160(4):1224-1239.e30. doi: 10.1053/j.gastro.2020.11.011. Epub 2020 Nov 14. Gastroenterology. 2021. PMID: 33197448 Free PMC article.
Comparative Efficacy and Safety of Endoscopic Modalities for Colorectal Cancer Screening in Inflammatory Bowel Disease: A Systematic Review and Network Meta-Analysis.
Sinopoulou V, Nigam GB, Gordon M, Ganeshan M, Tokonyai MR, Dolwani S, Iacucci M, Rutter M, Subramanian V, Wilson A; British Society of Gastroenterology Colorectal IBD Surveillance Guideline Development Group; East JE. Sinopoulou V, et al. Clin Gastroenterol Hepatol. 2024 Dec 13:S1542-3565(24)01073-5. doi: 10.1016/j.cgh.2024.11.008. Online ahead of print. Clin Gastroenterol Hepatol. 2024. PMID: 39675405 Free article.
Low coverage whole genome sequencing of low-grade dysplasia strongly predicts colorectal cancer risk in ulcerative colitis.
Al Bakir I, Curtius K, Cresswell GD, Grant HE, Nasreddin N, Smith K, Nowinski S, Guo Q, Belnoue-Davis HL, Fisher J, Clarke T, Kimberley C, Mossner M, Dunne PD, Loughrey MB, Speight A, East JE, Wright NA, Rodriguez-Justo M, Jansen M, Moorghen M, Baker AM, Leedham SJ, Hart AL, Graham TA. Al Bakir I, et al. Among authors: leedham sj. medRxiv [Preprint]. 2024 Jul 8:2024.07.08.24309811. doi: 10.1101/2024.07.08.24309811. medRxiv. 2024. PMID: 39040198 Free PMC article. Preprint.
Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis.
Lannagan TRM, Lee YK, Wang T, Roper J, Bettington ML, Fennell L, Vrbanac L, Jonavicius L, Somashekar R, Gieniec K, Yang M, Ng JQ, Suzuki N, Ichinose M, Wright JA, Kobayashi H, Putoczki TL, Hayakawa Y, Leedham SJ, Abud HE, Yilmaz ÖH, Marker J, Klebe S, Wirapati P, Mukherjee S, Tejpar S, Leggett BA, Whitehall VLJ, Worthley DL, Woods SL. Lannagan TRM, et al. Among authors: leedham sj. Gut. 2019 Apr;68(4):684-692. doi: 10.1136/gutjnl-2017-315920. Epub 2018 Apr 17. Gut. 2019. PMID: 29666172 Free PMC article.
Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification.
Kleeman SO, Koelzer VH, Jones HJ, Vazquez EG, Davis H, East JE, Arnold R, Koppens MA, Blake A, Domingo E, Cunningham C, Beggs AD, Pestinger V, Loughrey MB, Wang LM, Lannagan TR, Woods SL, Worthley D, Consortium SC, Tomlinson I, Dunne PD, Maughan T, Leedham SJ. Kleeman SO, et al. Among authors: leedham sj. Gut. 2020 Jun;69(6):1092-1103. doi: 10.1136/gutjnl-2019-319126. Epub 2019 Sep 28. Gut. 2020. PMID: 31563876 Free PMC article.
Advances in colon cancer research: in vitro and animal models.
Lannagan TR, Jackstadt R, Leedham SJ, Sansom OJ. Lannagan TR, et al. Among authors: leedham sj. Curr Opin Genet Dev. 2021 Feb;66:50-56. doi: 10.1016/j.gde.2020.12.003. Epub 2021 Jan 7. Curr Opin Genet Dev. 2021. PMID: 33422950 Free PMC article. Review.
Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration.
Koppens MAJ, Davis H, Valbuena GN, Mulholland EJ, Nasreddin N, Colombe M, Antanaviciute A, Biswas S, Friedrich M, Lee L; Oxford IBD Cohort Investigators; Wang LM, Koelzer VH, East JE, Simmons A, Winton DJ, Leedham SJ. Koppens MAJ, et al. Among authors: leedham sj. Gastroenterology. 2021 Jul;161(1):239-254.e9. doi: 10.1053/j.gastro.2021.03.052. Epub 2021 Apr 2. Gastroenterology. 2021. PMID: 33819486 Free PMC article.
109 results