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Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.
Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY. Maedler K, et al. Among authors: storling j. Diabetes. 2004 Jul;53(7):1706-13. doi: 10.2337/diabetes.53.7.1706. Diabetes. 2004. PMID: 15220194
Type 1 database mellitus: an inflammatory disease of the islet.
Bergholdt R, Heding P, Nielsen K, Nolsøe R, Sparre T, Størling J, Nerup J, Pociot F, Mandrup-Poulsen T. Bergholdt R, et al. Among authors: storling j. Adv Exp Med Biol. 2004;552:129-53. Adv Exp Med Biol. 2004. PMID: 15622962 Review. No abstract available.
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL. Cardozo AK, et al. Among authors: storling j. Diabetes. 2005 Feb;54(2):452-61. doi: 10.2337/diabetes.54.2.452. Diabetes. 2005. PMID: 15677503
Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3.
Karlsen AE, Størling ZM, Sparre T, Larsen MR, Mahmood A, Størling J, Roepstorff P, Wrzesinski K, Larsen PM, Fey S, Nielsen K, Heding P, Ricordi C, Johannesen J, Kristiansen OP, Christensen UB, Kockum I, Luthman H, Nerup J, Pociot F. Karlsen AE, et al. Among authors: storling zm, storling j. Biochem Biophys Res Commun. 2006 May 26;344(1):406-15. doi: 10.1016/j.bbrc.2006.03.105. Epub 2006 Mar 29. Biochem Biophys Res Commun. 2006. PMID: 16600178
Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.
Grunnet LG, Aikin R, Tonnesen MF, Paraskevas S, Blaabjerg L, Størling J, Rosenberg L, Billestrup N, Maysinger D, Mandrup-Poulsen T. Grunnet LG, et al. Among authors: storling j. Diabetes. 2009 Aug;58(8):1807-15. doi: 10.2337/db08-0178. Epub 2009 May 26. Diabetes. 2009. PMID: 19470609 Free PMC article.
Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis.
Berchtold LA, Størling ZM, Ortis F, Lage K, Bang-Berthelsen C, Bergholdt R, Hald J, Brorsson CA, Eizirik DL, Pociot F, Brunak S, Størling J. Berchtold LA, et al. Among authors: storling zm, storling j. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):E681-8. doi: 10.1073/pnas.1104384108. Epub 2011 Jun 24. Proc Natl Acad Sci U S A. 2011. PMID: 21705657 Free PMC article.
79 results