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JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome.
Tuttle KD, Waugh KA, Araya P, Minter R, Orlicky DJ, Ludwig M, Andrysik Z, Burchill MA, Tamburini BAJ, Sempeck C, Smith K, Granrath R, Tracy D, Baxter J, Espinosa JM, Sullivan KD. Tuttle KD, et al. Among authors: smith k. Cell Rep. 2020 Nov 17;33(7):108407. doi: 10.1016/j.celrep.2020.108407. Cell Rep. 2020. PMID: 33207208 Free PMC article.
Trisomy 21 consistently activates the interferon response.
Sullivan KD, Lewis HC, Hill AA, Pandey A, Jackson LP, Cabral JM, Smith KP, Liggett LA, Gomez EB, Galbraith MD, DeGregori J, Espinosa JM. Sullivan KD, et al. Elife. 2016 Jul 29;5:e16220. doi: 10.7554/eLife.16220. Elife. 2016. PMID: 27472900 Free PMC article.
Red blood cell metabolism in Down syndrome: hints on metabolic derangements in aging.
Culp-Hill R, Zheng C, Reisz JA, Smith K, Rachubinski A, Nemkov T, Butcher E, Granrath R, Hansen KC, Espinosa JM, D'Alessandro A. Culp-Hill R, et al. Among authors: smith k. Blood Adv. 2017 Dec 21;1(27):2776-2780. doi: 10.1182/bloodadvances.2017011957. eCollection 2017 Dec 26. Blood Adv. 2017. PMID: 29296929 Free PMC article.
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors.
Powers RK, Culp-Hill R, Ludwig MP, Smith KP, Waugh KA, Minter R, Tuttle KD, Lewis HC, Rachubinski AL, Granrath RE, Carmona-Iragui M, Wilkerson RB, Kahn DE, Joshi M, Lleó A, Blesa R, Fortea J, D'Alessandro A, Costello JC, Sullivan KD, Espinosa JM. Powers RK, et al. Among authors: smith kp. Nat Commun. 2019 Oct 18;10(1):4766. doi: 10.1038/s41467-019-12739-9. Nat Commun. 2019. PMID: 31628327 Free PMC article.
Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity.
Araya P, Waugh KA, Sullivan KD, Núñez NG, Roselli E, Smith KP, Granrath RE, Rachubinski AL, Enriquez Estrada B, Butcher ET, Minter R, Tuttle KD, Bruno TC, Maccioni M, Espinosa JM. Araya P, et al. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24231-24241. doi: 10.1073/pnas.1908129116. Epub 2019 Nov 7. Proc Natl Acad Sci U S A. 2019. PMID: 31699819 Free PMC article.
Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome.
Waugh KA, Araya P, Pandey A, Jordan KR, Smith KP, Granrath RE, Khanal S, Butcher ET, Estrada BE, Rachubinski AL, McWilliams JA, Minter R, Dimasi T, Colvin KL, Baturin D, Pham AT, Galbraith MD, Bartsch KW, Yeager ME, Porter CC, Sullivan KD, Hsieh EW, Espinosa JM. Waugh KA, et al. Cell Rep. 2019 Nov 12;29(7):1893-1908.e4. doi: 10.1016/j.celrep.2019.10.038. Cell Rep. 2019. PMID: 31722205 Free PMC article. Clinical Trial.
Seroconversion stages COVID19 into distinct pathophysiological states.
Galbraith MD, Kinning KT, Sullivan KD, Baxter R, Araya P, Jordan KR, Russell S, Smith KP, Granrath RE, Shaw J, Dzieciatkowska M, Ghosh T, Monte AA, D'Alessandro A, Hansen KC, Bennett TD, Hsieh EWY, Espinosa JM. Galbraith MD, et al. medRxiv [Preprint]. 2020 Dec 7:2020.12.05.20244442. doi: 10.1101/2020.12.05.20244442. medRxiv. 2020. Update in: Elife. 2021 Mar 16;10:e65508. doi: 10.7554/eLife.65508 PMID: 33330890 Free PMC article. Updated. Preprint.
Seroconversion stages COVID19 into distinct pathophysiological states.
Galbraith MD, Kinning KT, Sullivan KD, Baxter R, Araya P, Jordan KR, Russell S, Smith KP, Granrath RE, Shaw JR, Dzieciatkowska M, Ghosh T, Monte AA, D'Alessandro A, Hansen KC, Benett TD, Hsieh EW, Espinosa JM. Galbraith MD, et al. Elife. 2021 Mar 16;10:e65508. doi: 10.7554/eLife.65508. Elife. 2021. PMID: 33724185 Free PMC article.
The COVIDome Explorer Researcher Portal.
Sullivan KD, Galbraith MD, Kinning KT, Bartsch K, Levinsky N, Araya P, Smith KP, Granrath RE, Shaw JR, Baxter R, Jordan KR, Russell S, Dzieciatkowska M, Reisz JA, Gamboni F, Cendali F, Ghosh T, Monte AA, Bennett TD, Miller MG, Hsieh EWY, D'Alessandro A, Hansen KC, Espinosa JM. Sullivan KD, et al. Among authors: smith kp. medRxiv [Preprint]. 2021 Mar 8:2021.03.04.21252945. doi: 10.1101/2021.03.04.21252945. medRxiv. 2021. Update in: Cell Rep. 2021 Aug 17;36(7):109527. doi: 10.1016/j.celrep.2021.109527 PMID: 33758879 Free PMC article. Updated. Preprint.
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