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Page 1
From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement.
Mostinski Y, Heynen GJJE, López-Alberca MP, Paul J, Miksche S, Radetzki S, Schaller D, Shanina E, Seyffarth C, Kolomeets Y, Ziebart N, de Schryver J, Oestreich S, Neuenschwander M, Roske Y, Heinemann U, Rademacher C, Volkamer A, von Kries JP, Birchmeier W, Nazaré M. Mostinski Y, et al. Among authors: lopez alberca mp. J Med Chem. 2020 Dec 10;63(23):14780-14804. doi: 10.1021/acs.jmedchem.0c01265. Epub 2020 Nov 19. J Med Chem. 2020. PMID: 33210922
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Ruess DA, Heynen GJ, Ciecielski KJ, Ai J, Berninger A, Kabacaoglu D, Görgülü K, Dantes Z, Wörmann SM, Diakopoulos KN, Karpathaki AF, Kowalska M, Kaya-Aksoy E, Song L, van der Laan EAZ, López-Alberca MP, Nazaré M, Reichert M, Saur D, Erkan MM, Hopt UT, Sainz B Jr, Birchmeier W, Schmid RM, Lesina M, Algül H. Ruess DA, et al. Among authors: lopez alberca mp. Nat Med. 2018 Jul;24(7):954-960. doi: 10.1038/s41591-018-0024-8. Epub 2018 May 28. Nat Med. 2018. PMID: 29808009 Free article.
Discovery of Pyrrolidine-2,3-diones as Novel Inhibitors of P. aeruginosa PBP3.
López-Pérez A, Freischem S, Grimm I, Weiergräber O, Dingley AJ, López-Alberca MP, Waldmann H, Vollmer W, Kumar K, Vuong C. López-Pérez A, et al. Among authors: lopez alberca mp. Antibiotics (Basel). 2021 May 4;10(5):529. doi: 10.3390/antibiotics10050529. Antibiotics (Basel). 2021. PMID: 34064358 Free PMC article.
Nature-Inspired Drugs: Expanding Horizons of Contemporary Therapeutics.
Rasul A, Hussain G, Selamoglu Z, López-Alberca MP. Rasul A, et al. Among authors: lopez alberca mp. Adv Pharmacol Sci. 2019 May 2;2019:6218183. doi: 10.1155/2019/6218183. eCollection 2019. Adv Pharmacol Sci. 2019. PMID: 31191650 Free PMC article. No abstract available.