Kunkel MT - Search Results

1

Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.

Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J. Zhou X, et al. Among authors: kunkel mt. Nat Commun. 2020 Nov 30;11(1):6088. doi: 10.1038/s41467-020-19937-w. Nat Commun. 2020. PMID: 33257668 Free PMC article.

2

Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter.

Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC. Kunkel MT, et al. J Biol Chem. 2005 Feb 18;280(7):5581-7. doi: 10.1074/jbc.M411534200. Epub 2004 Dec 6. J Biol Chem. 2005. PMID: 15583002 Free PMC article.

3

Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling.

Gallegos LL, Kunkel MT, Newton AC. Gallegos LL, et al. Among authors: kunkel mt. J Biol Chem. 2006 Oct 13;281(41):30947-56. doi: 10.1074/jbc.M603741200. Epub 2006 Aug 10. J Biol Chem. 2006. PMID: 16901905 Free article.

4

Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter.

Kunkel MT, Toker A, Tsien RY, Newton AC. Kunkel MT, et al. J Biol Chem. 2007 Mar 2;282(9):6733-42. doi: 10.1074/jbc.M608086200. Epub 2006 Dec 21. J Biol Chem. 2007. PMID: 17189263 Free PMC article.

5

The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity.

Kunkel MT, Garcia EL, Kajimoto T, Hall RA, Newton AC. Kunkel MT, et al. J Biol Chem. 2009 Sep 4;284(36):24653-61. doi: 10.1074/jbc.M109.024547. Epub 2009 Jul 6. J Biol Chem. 2009. PMID: 19581308 Free PMC article.

6

Calcium transduces plasma membrane receptor signals to produce diacylglycerol at Golgi membranes.

Kunkel MT, Newton AC. Kunkel MT, et al. J Biol Chem. 2010 Jul 23;285(30):22748-52. doi: 10.1074/jbc.C110.123133. Epub 2010 Jun 2. J Biol Chem. 2010. PMID: 20519514 Free PMC article.

7

Spatiotemporal Dynamics of Kinase Signaling Visualized by Targeted Reporters.

Kunkel MT, Newton AC. Kunkel MT, et al. Curr Protoc Chem Biol. 2009 Dec 1;1(1):17-18. doi: 10.1002/9780470559277.ch090106. Curr Protoc Chem Biol. 2009. PMID: 21804950 Free PMC article.

8

Imaging kinase activity at protein scaffolds.

Kunkel MT, Newton AC. Kunkel MT, et al. Methods Mol Biol. 2014;1071:129-37. doi: 10.1007/978-1-62703-622-1_10. Methods Mol Biol. 2014. PMID: 24052385 Free PMC article.

9

Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation.

Kunkel MT, Newton AC. Kunkel MT, et al. Chem Biol. 2015 Jan 22;22(1):98-106. doi: 10.1016/j.chembiol.2014.11.014. Epub 2014 Dec 31. Chem Biol. 2015. PMID: 25556943 Free PMC article.

10

Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity.

Balasuriya N, Kunkel MT, Liu X, Biggar KK, Li SS, Newton AC, O'Donoghue P. Balasuriya N, et al. Among authors: kunkel mt. J Biol Chem. 2018 Jul 6;293(27):10744-10756. doi: 10.1074/jbc.RA118.002357. Epub 2018 May 17. J Biol Chem. 2018. PMID: 29773654 Free PMC article.

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