Sinclair DA - Search Results

1

Reprogramming to recover youthful epigenetic information and restore vision.

Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Lu Y, et al. Among authors: sinclair da. Nature. 2020 Dec;588(7836):124-129. doi: 10.1038/s41586-020-2975-4. Epub 2020 Dec 2. Nature. 2020. PMID: 33268865 Free PMC article.

2

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Gomes AP, et al. Among authors: sinclair da. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. Cell. 2013. PMID: 24360282 Free PMC article.

3

When stem cells grow old: phenotypes and mechanisms of stem cell aging.

Schultz MB, Sinclair DA. Schultz MB, et al. Among authors: sinclair da. Development. 2016 Jan 1;143(1):3-14. doi: 10.1242/dev.130633. Development. 2016. PMID: 26732838 Free PMC article. Review.

4

Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency.

Cagnone GL, Tsai TS, Makanji Y, Matthews P, Gould J, Bonkowski MS, Elgass KD, Wong AS, Wu LE, McKenzie M, Sinclair DA, St John JC. Cagnone GL, et al. Among authors: sinclair da. Sci Rep. 2016 Mar 18;6:23229. doi: 10.1038/srep23229. Sci Rep. 2016. PMID: 26987907 Free PMC article.

5

Why NAD(+) Declines during Aging: It's Destroyed.

Schultz MB, Sinclair DA. Schultz MB, et al. Among authors: sinclair da. Cell Metab. 2016 Jun 14;23(6):965-966. doi: 10.1016/j.cmet.2016.05.022. Cell Metab. 2016. PMID: 27304496 Free PMC article.

6

Slowing ageing by design: the rise of NAD⁺ and sirtuin-activating compounds.

Bonkowski MS, Sinclair DA. Bonkowski MS, et al. Among authors: sinclair da. Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690. doi: 10.1038/nrm.2016.93. Epub 2016 Aug 24. Nat Rev Mol Cell Biol. 2016. PMID: 27552971 Free PMC article. Review.

7

A conserved NAD⁺ binding pocket that regulates protein-protein interactions during aging.

Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. Li J, et al. Among authors: sinclair da. Science. 2017 Mar 24;355(6331):1312-1317. doi: 10.1126/science.aad8242. Science. 2017. PMID: 28336669 Free PMC article.

8

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.

Rajman L, Chwalek K, Sinclair DA. Rajman L, et al. Among authors: sinclair da. Cell Metab. 2018 Mar 6;27(3):529-547. doi: 10.1016/j.cmet.2018.02.011. Cell Metab. 2018. PMID: 29514064 Free PMC article. Review.

9

Impairment of an Endothelial NAD⁺-H₂S Signaling Network Is a Reversible Cause of Vascular Aging.

Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Das A, et al. Among authors: sinclair da. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. Cell. 2018. PMID: 29570999 Free PMC article.

10

Assays for NAD⁺-Dependent Reactions and NAD⁺ Metabolites.

Schultz MB, Lu Y, Braidy N, Sinclair DA. Schultz MB, et al. Among authors: sinclair da. Methods Mol Biol. 2018;1813:77-90. doi: 10.1007/978-1-4939-8588-3_6. Methods Mol Biol. 2018. PMID: 30097862 Free PMC article.

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