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HDP-101, an Anti-BCMA Antibody-Drug Conjugate, Safely Delivers Amanitin to Induce Cell Death in Proliferating and Resting Multiple Myeloma Cells.
Figueroa-Vazquez V, Ko J, Breunig C, Baumann A, Giesen N, Pálfi A, Müller C, Lutz C, Hechler T, Kulke M, Müller-Tidow C, Krämer A, Goldschmidt H, Pahl A, Raab MS. Figueroa-Vazquez V, et al. Among authors: kulke m. Mol Cancer Ther. 2021 Feb;20(2):367-378. doi: 10.1158/1535-7163.MCT-20-0287. Epub 2020 Dec 9. Mol Cancer Ther. 2021. PMID: 33298585
Antibody-drug conjugate payloads.
Anderl J, Faulstich H, Hechler T, Kulke M. Anderl J, et al. Among authors: kulke m. Methods Mol Biol. 2013;1045:51-70. doi: 10.1007/978-1-62703-541-5_4. Methods Mol Biol. 2013. PMID: 23913141 Review.
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma.
Noll EM, Eisen C, Stenzinger A, Espinet E, Muckenhuber A, Klein C, Vogel V, Klaus B, Nadler W, Rösli C, Lutz C, Kulke M, Engelhardt J, Zickgraf FM, Espinosa O, Schlesner M, Jiang X, Kopp-Schneider A, Neuhaus P, Bahra M, Sinn BV, Eils R, Giese NA, Hackert T, Strobel O, Werner J, Büchler MW, Weichert W, Trumpp A, Sprick MR. Noll EM, et al. Among authors: kulke m. Nat Med. 2016 Mar;22(3):278-87. doi: 10.1038/nm.4038. Epub 2016 Feb 8. Nat Med. 2016. PMID: 26855150 Free PMC article.
Targeted immunotherapy for HER2-low breast cancer with 17p loss.
Li Y, Sun Y, Kulke M, Hechler T, Van der Jeught K, Dong T, He B, Miller KD, Radovich M, Schneider BP, Pahl A, Zhang X, Lu X. Li Y, et al. Among authors: kulke m. Sci Transl Med. 2021 Feb 10;13(580):eabc6894. doi: 10.1126/scitranslmed.abc6894. Sci Transl Med. 2021. PMID: 33568521 Free PMC article.
Site-Specific Modification of Native IgGs with Flexible Drug-Load.
Wehrmüller JE, Frei JC, Hechler T, Kulke M, Pahl A, Béhé M, Schibli R, Spycher PR. Wehrmüller JE, et al. Among authors: kulke m. Chembiochem. 2024 Sep 21:e202400511. doi: 10.1002/cbic.202400511. Online ahead of print. Chembiochem. 2024. PMID: 39305147
284 results