Vettermann C - Search Results

1

Early Phase Clinical Immunogenicity of Valoctocogene Roxaparvovec, an AAV5-Mediated Gene Therapy for Hemophilia A.

Long BR, Veron P, Kuranda K, Hardet R, Mitchell N, Hayes GM, Wong WY, Lau K, Li M, Hock MB, Zoog SJ, Vettermann C, Mingozzi F, Schweighardt B. Long BR, et al. Among authors: vettermann c. Mol Ther. 2021 Feb 3;29(2):597-610. doi: 10.1016/j.ymthe.2020.12.008. Epub 2020 Dec 10. Mol Ther. 2021. PMID: 33309883 Free PMC article.

2

Validation of an IFN-gamma ELISpot assay to measure cellular immune responses against viral antigens in non-human primates.

Yang F, Patton K, Kasprzyk T, Long B, Gupta S, Zoog SJ, Tracy K, Vettermann C. Yang F, et al. Among authors: vettermann c. Gene Ther. 2022 Feb;29(1-2):41-54. doi: 10.1038/s41434-020-00214-w. Epub 2021 Jan 11. Gene Ther. 2022. PMID: 33432123 Free PMC article.

3

Ultra-sensitive AAV capsid detection by immunocapture-based qPCR following factor VIII gene transfer.

Sandza K, Clark A, Koziol E, Akeefe H, Yang F, Holcomb J, Patton K, Hammon K, Mitchell N, Wong WY, Zoog SJ, Kim B, Henshaw J, Vettermann C. Sandza K, et al. Among authors: vettermann c. Gene Ther. 2022 Feb;29(1-2):94-105. doi: 10.1038/s41434-021-00287-1. Epub 2021 Aug 23. Gene Ther. 2022. PMID: 34421119 Free PMC article.

4

The Impact of Pre-existing Immunity on the Non-clinical Pharmacodynamics of AAV5-Based Gene Therapy.

Long BR, Sandza K, Holcomb J, Crockett L, Hayes GM, Arens J, Fonck C, Tsuruda LS, Schweighardt B, O'Neill CA, Zoog S, Vettermann C. Long BR, et al. Among authors: vettermann c. Mol Ther Methods Clin Dev. 2019 Apr 11;13:440-452. doi: 10.1016/j.omtm.2019.03.006. eCollection 2019 Jun 14. Mol Ther Methods Clin Dev. 2019. PMID: 31193016 Free PMC article.

5

Strategy to detect pre-existing immunity to AAV gene therapy.

Falese L, Sandza K, Yates B, Triffault S, Gangar S, Long B, Tsuruda L, Carter B, Vettermann C, Zoog SJ, Fong S. Falese L, et al. Among authors: vettermann c. Gene Ther. 2017 Dec;24(12):768-778. doi: 10.1038/gt.2017.95. Epub 2017 Nov 6. Gene Ther. 2017. PMID: 29106404 Free PMC article.

6

Activity of transgene-produced B-domain-deleted factor VIII in human plasma following AAV5 gene therapy.

Rosen S, Tiefenbacher S, Robinson M, Huang M, Srimani J, Mackenzie D, Christianson T, Pasi KJ, Rangarajan S, Symington E, Giermasz A, Pierce GF, Kim B, Zoog SJ, Vettermann C. Rosen S, et al. Among authors: vettermann c. Blood. 2020 Nov 26;136(22):2524-2534. doi: 10.1182/blood.2020005683. Blood. 2020. PMID: 32915950 Free PMC article. Clinical Trial.

7

Monitoring cell-mediated immune responses in AAV gene therapy clinical trials using a validated IFN-γ ELISpot method.

Patton KS, Harrison MT, Long BR, Lau K, Holcomb J, Owen R, Kasprzyk T, Janetzki S, Zoog SJ, Vettermann C. Patton KS, et al. Among authors: vettermann c. Mol Ther Methods Clin Dev. 2021 May 29;22:183-195. doi: 10.1016/j.omtm.2021.05.012. eCollection 2021 Sep 10. Mol Ther Methods Clin Dev. 2021. PMID: 34485604 Free PMC article.

8

Confirmatory detection of neutralizing antibodies to AAV gene therapy using a cell-based transduction inhibition assay.

Kasprzyk T, Triffault S, Long BR, Zoog SJ, Vettermann C. Kasprzyk T, et al. Among authors: vettermann c. Mol Ther Methods Clin Dev. 2022 Jan 7;24:222-229. doi: 10.1016/j.omtm.2022.01.004. eCollection 2022 Mar 10. Mol Ther Methods Clin Dev. 2022. PMID: 35141351 Free PMC article.

9

AAV5-Factor VIII Gene Transfer in Severe Hemophilia A.

Rangarajan S, Walsh L, Lester W, Perry D, Madan B, Laffan M, Yu H, Vettermann C, Pierce GF, Wong WY, Pasi KJ. Rangarajan S, et al. Among authors: vettermann c. N Engl J Med. 2017 Dec 28;377(26):2519-2530. doi: 10.1056/NEJMoa1708483. Epub 2017 Dec 9. N Engl J Med. 2017. PMID: 29224506 Free article. Clinical Trial.

10

Evaluation of the Humoral Response to Adeno-Associated Virus-Based Gene Therapy Modalities Using Total Antibody Assays.

Gorovits B, Azadeh M, Buchlis G, Harrison T, Havert M, Jawa V, Long B, McNally J, Milton M, Nelson R, O'Dell M, Richards K, Vettermann C, Wu B. Gorovits B, et al. Among authors: vettermann c. AAPS J. 2021 Sep 16;23(6):108. doi: 10.1208/s12248-021-00628-3. AAPS J. 2021. PMID: 34529177 Free PMC article. Review.

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