Chapel S - Search Results

1

Concentration-QTc Modeling of Ozanimod's Major Active Metabolites in Adult Healthy Subjects.

Briggs E, Chapel S, Zhang P, Palmisano M, Tran JQ. Briggs E, et al. Among authors: chapel s. CPT Pharmacometrics Syst Pharmacol. 2021 Feb;10(2):119-126. doi: 10.1002/psp4.12580. Epub 2021 Jan 5. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 33314790 Free PMC article. Clinical Trial.

2

Exposure-response analysis in patients with schizophrenia to assess the effect of asenapine on QTc prolongation.

Chapel S, Hutmacher MM, Haig G, Bockbrader H, de Greef R, Preskorn SH, Lalonde RL. Chapel S, et al. J Clin Pharmacol. 2009 Nov;49(11):1297-308. doi: 10.1177/0091270009344855. J Clin Pharmacol. 2009. PMID: 19843656 Clinical Trial.

3

Clinical Pharmacokinetics and Pharmacodynamics of Dalcetrapib.

Black DM, Bentley D, Chapel S, Lee J, Briggs E, Heinonen T. Black DM, et al. Among authors: chapel s. Clin Pharmacokinet. 2018 Nov;57(11):1359-1367. doi: 10.1007/s40262-018-0656-3. Clin Pharmacokinet. 2018. PMID: 29730761 Free PMC article. Review.

4

Population Pharmacokinetics of Pregabalin Extended-Release in Healthy Volunteers and Patients With Postherpetic Neuralgia, Fibromyalgia, and Partial-Onset Seizures.

Chew M, Ma G, Xie R, Bockbrader H, Chapel S, Marshall S. Chew M, et al. Among authors: chapel s. J Clin Pharmacol. 2019 Nov;59(11):1527-1542. doi: 10.1002/jcph.1450. Epub 2019 Jun 11. J Clin Pharmacol. 2019. PMID: 31183879 Clinical Trial.

5

Population pharmacokinetic analysis of apomorphine sublingual film or subcutaneous apomorphine in healthy subjects and patients with Parkinson's disease.

Agbo F, Crass RL, Chiu YY, Chapel S, Galluppi G, Blum D, Navia B. Agbo F, et al. Among authors: chapel s. Clin Transl Sci. 2021 Jul;14(4):1464-1475. doi: 10.1111/cts.13008. Epub 2021 May 2. Clin Transl Sci. 2021. PMID: 33650272 Free PMC article.

6

Integrated Exposure-Response of Dupilumab in Children, Adolescents, and Adults With Atopic Dermatitis Using Categorical and Continuous Efficacy Assessments: A Population Analysis.

Briggs E, Kamal MA, Kosloski MP, Linsmeier I, Jusko N, Dolphin N, Chittenden J, Simpson EL, Paller AS, Siegfried EC, Shumel B, Levit NA, Bansal A, Davis JD, Chapel S, Smith DE, Huniti N. Briggs E, et al. Among authors: chapel s. Pharm Res. 2023 Nov;40(11):2653-2666. doi: 10.1007/s11095-023-03616-8. Epub 2023 Dec 11. Pharm Res. 2023. PMID: 38082089 Free PMC article.

7

Performance characteristics for some typical QT study designs under the ICH E-14 guidance.

Hutmacher MM, Chapel S, Agin MA, Fleishaker JC, Lalonde RL. Hutmacher MM, et al. Among authors: chapel s. J Clin Pharmacol. 2008 Feb;48(2):215-24. doi: 10.1177/0091270007311921. J Clin Pharmacol. 2008. PMID: 18199896

8

Comparison of QTc data analysis methods recommended by the ICH E14 guidance and exposure-response analysis: case study of a thorough QT study of asenapine.

Chapel S, Hutmacher MM, Bockbrader H, de Greef R, Lalonde RL. Chapel S, et al. Clin Pharmacol Ther. 2011 Jan;89(1):75-80. doi: 10.1038/clpt.2010.220. Epub 2010 Nov 24. Clin Pharmacol Ther. 2011. PMID: 21107314 Clinical Trial.

9

Population pharmacokinetics of naloxegol in a population of 1247 healthy subjects and patients.

Al-Huniti N, Chapel S, Xu H, Bui KH, Sostek M. Al-Huniti N, et al. Among authors: chapel s. Br J Clin Pharmacol. 2016 Jan;81(1):89-100. doi: 10.1111/bcp.12756. Epub 2015 Oct 27. Br J Clin Pharmacol. 2016. PMID: 26317320 Free PMC article.

10

Updated Population Pharmacokinetic Model of Cabozantinib Integrating Various Cancer Types Including Hepatocellular Carcinoma.

Nguyen L, Chapel S, Tran BD, Lacy S. Nguyen L, et al. Among authors: chapel s. J Clin Pharmacol. 2019 Nov;59(11):1551-1561. doi: 10.1002/jcph.1467. Epub 2019 Jun 11. J Clin Pharmacol. 2019. PMID: 31187515 Free PMC article. Clinical Trial.

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