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Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance.
Machado S, Silva A, De Sousa-Coelho AL, Duarte I, Grenho I, Santos B, Mayoral-Varo V, Megias D, Sánchez-Cabo F, Dopazo A, Ferreira BI, Link W. Machado S, et al. Among authors: link w. Cancers (Basel). 2020 Dec 9;12(12):3689. doi: 10.3390/cancers12123689. Cancers (Basel). 2020. PMID: 33316942 Free PMC article.
A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes.
Hill R, Kalathur RK, Callejas S, Colaço L, Brandão R, Serelde B, Cebriá A, Blanco-Aparicio C, Pastor J, Futschik M, Dopazo A, Link W. Hill R, et al. Among authors: link w. Breast Cancer Res. 2014 Dec 9;16(6):482. doi: 10.1186/s13058-014-0482-y. Breast Cancer Res. 2014. PMID: 25488803 Free PMC article.
TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT.
Hill R, Madureira PA, Ferreira B, Baptista I, Machado S, Colaço L, Dos Santos M, Liu N, Dopazo A, Ugurel S, Adrienn A, Kiss-Toth E, Isbilen M, Gure AO, Link W. Hill R, et al. Among authors: link w. Nat Commun. 2017 Mar 9;8:14687. doi: 10.1038/ncomms14687. Nat Commun. 2017. Retraction in: Nat Commun. 2023 Jul 19;14(1):4341. doi: 10.1038/s41467-023-40050-1. PMID: 28276427 Free PMC article. Retracted.
The Emerging Therapeutic Landscape of Advanced Melanoma.
Henriques V, Martins T, Link W, Ferreira BI. Henriques V, et al. Among authors: link w. Curr Pharm Des. 2018;24(5):549-558. doi: 10.2174/1381612824666180125093357. Curr Pharm Des. 2018. PMID: 29366407 Review.
Adaptive mechanisms of resistance to anti-neoplastic agents.
Ferreira BI, Lie MK, Engelsen AST, Machado S, Link W, Lorens JB. Ferreira BI, et al. Among authors: link w. Medchemcomm. 2016 Oct 21;8(1):53-66. doi: 10.1039/c6md00394j. eCollection 2017 Jan 1. Medchemcomm. 2016. PMID: 30108690 Free PMC article. Review.
166 results