Clark KR - Search Results

1

Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands.

Ferri E, Le Thomas A, Wallweber HA, Day ES, Walters BT, Kaufman SE, Braun MG, Clark KR, Beresini MH, Mortara K, Chen YA, Canter B, Phung W, Liu PS, Lammens A, Ashkenazi A, Rudolph J, Wang W. Ferri E, et al. Among authors: clark kr. Nat Commun. 2020 Dec 14;11(1):6387. doi: 10.1038/s41467-020-19974-5. Nat Commun. 2020. PMID: 33318494 Free PMC article.

2

Transfer of a protein binding epitope to a minimal designed peptide.

Quan C, Skelton NJ, Clark K, Jackson DY, Renz ME, Chiu HH, Keating SM, Beresini MH, Fong S, Artis DR. Quan C, et al. Biopolymers. 1998;47(4):265-75. doi: 10.1002/(SICI)1097-0282(1998)47:4<265::AID-BIP2>3.0.CO;2-K. Biopolymers. 1998. PMID: 10036968

3

ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.

Camenisch G, Pisabarro MT, Sherman D, Kowalski J, Nagel M, Hass P, Xie MH, Gurney A, Bodary S, Liang XH, Clark K, Beresini M, Ferrara N, Gerber HP. Camenisch G, et al. J Biol Chem. 2002 May 10;277(19):17281-90. doi: 10.1074/jbc.M109768200. Epub 2002 Feb 27. J Biol Chem. 2002. PMID: 11877390 Free article.

4

Selective alpha4beta7 integrin antagonists and their potential as antiinflammatory agents.

Dubree NJ, Artis DR, Castanedo G, Marsters J, Sutherlin D, Caris L, Clark K, Keating SM, Beresini MH, Chiu H, Fong S, Lowman HB, Skelton NJ, Jackson DY. Dubree NJ, et al. J Med Chem. 2002 Aug 1;45(16):3451-7. doi: 10.1021/jm020033k. J Med Chem. 2002. PMID: 12139455

5

Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.

Castanedo GM, Sailes FC, Dubree NJ, Nicholas JB, Caris L, Clark K, Keating SM, Beresini MH, Chiu H, Fong S, Marsters JC Jr, Jackson DY, Sutherlin DP. Castanedo GM, et al. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2913-7. doi: 10.1016/s0960-894x(02)00597-8. Bioorg Med Chem Lett. 2002. PMID: 12270174

6

N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship.

Burdick DJ, Paris K, Weese K, Stanley M, Beresini M, Clark K, McDowell RS, Marsters JC, Gadek TR. Burdick DJ, et al. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1015-8. doi: 10.1016/s0960-894x(03)00084-2. Bioorg Med Chem Lett. 2003. PMID: 12643901

7

N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: structure-activity relationship of the benzoyl moiety.

Burdick DJ, Marsters JC Jr, Aliagas-Martin I, Stanley M, Beresini M, Clark K, McDowell RS, Gadek TR. Burdick DJ, et al. Bioorg Med Chem Lett. 2004 May 3;14(9):2055-9. doi: 10.1016/j.bmcl.2004.02.046. Bioorg Med Chem Lett. 2004. PMID: 15080978

8

Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.

Keating SM, Clark KR, Stefanich LD, Arellano F, Edwards CP, Bodary SC, Spencer SA, Gadek TR, Marsters JC Jr, Beresini MH. Keating SM, et al. Among authors: clark kr. Protein Sci. 2006 Feb;15(2):290-303. doi: 10.1110/ps.051583406. Epub 2005 Dec 29. Protein Sci. 2006. PMID: 16384997 Free PMC article.

9

Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates.

Liu Y, Beresini MH, Johnson A, Mintzer R, Shah K, Clark K, Schmidt S, Lewis C, Liimatta M, Elliott LO, Gustafson A, Heise CE. Liu Y, et al. J Biomol Screen. 2012 Feb;17(2):225-36. doi: 10.1177/1087057111421525. Epub 2011 Sep 22. J Biomol Screen. 2012. PMID: 21940710

10

Small-Molecule Library Subset Screening as an Aid for Accelerating Lead Identification.

Beresini MH, Liu Y, Dawes TD, Clark KR, Orren L, Schmidt S, Turincio R, Jones SW, Rodriguez RA, Thana P, Hascall D, Gross DP, Skelton NJ. Beresini MH, et al. Among authors: clark kr. J Biomol Screen. 2014 Jun;19(5):758-70. doi: 10.1177/1087057114522515. Epub 2014 Feb 11. J Biomol Screen. 2014. PMID: 24518067

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