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Page 1
Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer.
Kurimchak AM, Shelton C, Duncan KE, Johnson KJ, Brown J, O'Brien S, Gabbasov R, Fink LS, Li Y, Lounsbury N, Abou-Gharbia M, Childers WE, Connolly DC, Chernoff J, Peterson JR, Duncan JS. Kurimchak AM, et al. Among authors: johnson kj. Cell Rep. 2016 Aug 2;16(5):1273-1286. doi: 10.1016/j.celrep.2016.06.091. Epub 2016 Jul 21. Cell Rep. 2016. PMID: 27452461 Free PMC article.
PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55α/PP2A reconstitution that triggers centrosome destabilization.
Zhao Z, Kurimchak A, Nikonova AS, Feiser F, Wasserman JS, Fowle H, Varughese T, Connors M, Johnson K, Makhov P, Lindskog C, Kolenko VM, Golemis EA, Duncan JS, Graña X. Zhao Z, et al. Oncogenesis. 2019 Dec 10;8(12):72. doi: 10.1038/s41389-019-0180-9. Oncogenesis. 2019. PMID: 31822657 Free PMC article.
Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma.
Kurimchak AM, Herrera-Montávez C, Brown J, Johnson KJ, Sodi V, Srivastava N, Kumar V, Deihimi S, O'Brien S, Peri S, Mantia-Smaldone GM, Jain A, Winters RM, Cai KQ, Chernoff J, Connolly DC, Duncan JS. Kurimchak AM, et al. Among authors: johnson kj. Sci Signal. 2020 Feb 18;13(619):eaax8238. doi: 10.1126/scisignal.aax8238. Sci Signal. 2020. PMID: 32071169 Free PMC article.
Kinome Profiling of Primary Endometrial Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies SRPK1 as Candidate Therapeutic Target.
Kurimchak AM, Kumar V, Herrera-Montávez C, Johnson KJ, Srivastava N, Davarajan K, Peri S, Cai KQ, Mantia-Smaldone GM, Duncan JS. Kurimchak AM, et al. Among authors: johnson kj. Mol Cell Proteomics. 2020 Dec;19(12):2068-2090. doi: 10.1074/mcp.RA120.002012. Epub 2020 Sep 29. Mol Cell Proteomics. 2020. PMID: 32994315 Free PMC article.
RAPID resistance to BET inhibitors is mediated by FGFR1 in glioblastoma.
Jermakowicz AM, Kurimchak AM, Johnson KJ, Bourgain-Guglielmetti F, Kaeppeli S, Affer M, Pradhyumnan H, Suter RK, Walters W, Cepero M, Duncan JS, Ayad NG. Jermakowicz AM, et al. Among authors: johnson kj. Sci Rep. 2024 Apr 23;14(1):9284. doi: 10.1038/s41598-024-60031-8. Sci Rep. 2024. PMID: 38654040 Free PMC article.
625 results