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AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.
Gorvin CM, Rogers A, Hastoy B, Tarasov AI, Frost M, Sposini S, Inoue A, Whyte MP, Rorsman P, Hanyaloglu AC, Breitwieser GE, Thakker RV. Gorvin CM, et al. Among authors: hanyaloglu ac. Cell Rep. 2018 Jan 23;22(4):1054-1066. doi: 10.1016/j.celrep.2017.12.089. Epub 2018 Jan 28. Cell Rep. 2018. PMID: 29420171 Free PMC article.
Genetically encoded intrabody sensors report the interaction and trafficking of β-arrestin 1 upon activation of G-protein-coupled receptors.
Baidya M, Kumari P, Dwivedi-Agnihotri H, Pandey S, Sokrat B, Sposini S, Chaturvedi M, Srivastava A, Roy D, Hanyaloglu AC, Bouvier M, Shukla AK. Baidya M, et al. Among authors: hanyaloglu ac. J Biol Chem. 2020 Jul 24;295(30):10153-10167. doi: 10.1074/jbc.RA120.013470. Epub 2020 May 21. J Biol Chem. 2020. PMID: 32439801 Free PMC article.
Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders.
Abbara A, Eng PC, Phylactou M, Clarke SA, Richardson R, Sykes CM, Phumsatitpong C, Mills E, Modi M, Izzi-Engbeaya C, Papadopoulou D, Purugganan K, Jayasena CN, Webber L, Salim R, Owen B, Bech P, Comninos AN, McArdle CA, Voliotis M, Tsaneva-Atanasova K, Moenter S, Hanyaloglu A, Dhillo WS. Abbara A, et al. J Clin Invest. 2020 Dec 1;130(12):6739-6753. doi: 10.1172/JCI139681. J Clin Invest. 2020. PMID: 33196464 Free PMC article. Clinical Trial.
73 results