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Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition.
Kennedy AJ, Sundström L, Geschwindner S, Poon EKY, Jiang Y, Chen R, Cooke R, Johnstone S, Madin A, Lim J, Liu Q, Lohman RJ, Nordqvist A, Fridén-Saxin M, Yang W, Brown DG, Fairlie DP, Dekker N. Kennedy AJ, et al. Among authors: sundstrom l. Commun Biol. 2020 Dec 17;3(1):782. doi: 10.1038/s42003-020-01504-0. Commun Biol. 2020. PMID: 33335291 Free PMC article.
Structural insight into allosteric modulation of protease-activated receptor 2.
Cheng RKY, Fiez-Vandal C, Schlenker O, Edman K, Aggeler B, Brown DG, Brown GA, Cooke RM, Dumelin CE, Doré AS, Geschwindner S, Grebner C, Hermansson NO, Jazayeri A, Johansson P, Leong L, Prihandoko R, Rappas M, Soutter H, Snijder A, Sundström L, Tehan B, Thornton P, Troast D, Wiggin G, Zhukov A, Marshall FH, Dekker N. Cheng RKY, et al. Among authors: sundstrom l. Nature. 2017 May 4;545(7652):112-115. doi: 10.1038/nature22309. Epub 2017 Apr 26. Nature. 2017. PMID: 28445455
Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target.
Brown DG, Brown GA, Centrella P, Certel K, Cooke RM, Cuozzo JW, Dekker N, Dumelin CE, Ferguson A, Fiez-Vandal C, Geschwindner S, Guié MA, Habeshian S, Keefe AD, Schlenker O, Sigel EA, Snijder A, Soutter HT, Sundström L, Troast DM, Wiggin G, Zhang J, Zhang Y, Clark MA. Brown DG, et al. Among authors: sundstrom l. SLAS Discov. 2018 Jun;23(5):429-436. doi: 10.1177/2472555217749847. Epub 2018 Jan 9. SLAS Discov. 2018. PMID: 29316408 Free article.
Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell.
Knerr L, Prakash TP, Lee R, Drury Iii WJ, Nikan M, Fu W, Pirie E, Maria L, Valeur E, Hayen A, Ölwegård-Halvarsson M, Broddefalk J, Ämmälä C, Østergaard ME, Meuller J, Sundström L, Andersson P, Janzén D, Jansson-Löfmark R, Seth PP, Andersson S. Knerr L, et al. Among authors: sundstrom l. J Am Chem Soc. 2021 Mar 10;143(9):3416-3429. doi: 10.1021/jacs.0c12043. Epub 2021 Feb 24. J Am Chem Soc. 2021. PMID: 33626278
Innovative developments and emerging technologies in RNA therapeutics.
Halloy F, Biscans A, Bujold KE, Debacker A, Hill AC, Lacroix A, Luige O, Strömberg R, Sundstrom L, Vogel J, Ghidini A. Halloy F, et al. Among authors: sundstrom l. RNA Biol. 2022;19(1):313-332. doi: 10.1080/15476286.2022.2027150. Epub 2021 Dec 31. RNA Biol. 2022. PMID: 35188077 Free PMC article.
Is GPR146 really the receptor for proinsulin C-peptide?
Lindfors L, Sundström L, Fröderberg Roth L, Meuller J, Andersson S, Kihlberg J. Lindfors L, et al. Among authors: sundstrom l. Bioorg Med Chem Lett. 2020 Jul 1;30(13):127208. doi: 10.1016/j.bmcl.2020.127208. Epub 2020 Apr 20. Bioorg Med Chem Lett. 2020. PMID: 32354568 Free article.
Targeted delivery of antisense oligonucleotides to pancreatic β-cells.
Ämmälä C, Drury WJ 3rd, Knerr L, Ahlstedt I, Stillemark-Billton P, Wennberg-Huldt C, Andersson EM, Valeur E, Jansson-Löfmark R, Janzén D, Sundström L, Meuller J, Claesson J, Andersson P, Johansson C, Lee RG, Prakash TP, Seth PP, Monia BP, Andersson S. Ämmälä C, et al. Among authors: sundstrom l. Sci Adv. 2018 Oct 17;4(10):eaat3386. doi: 10.1126/sciadv.aat3386. eCollection 2018 Oct. Sci Adv. 2018. PMID: 30345352 Free PMC article.
192 results